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B6db activities: 4.1.1.12

4.1.1.12
Description Aspartate 4-decarboxylase
Alternative names Aspartate-beta-decarboxylase;
Cysteine sulfinate desulfinase.
Catalyzed reaction L-aspartate = L-alanine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- Also catalyzes the decarboxylation of aminomalonate and the desulfination of 3-sulfino-L-alanine to sulfite and alanine.
-!- Formerly EC 4.1.1.10.
The only validated sequences are from bacteria. The activity occurs also in fungi and metazoa (the rat enzyme appears to be membrane-bound) but no sequences similar to the bacterial ones are found in the genomes of these organisms.
PDB 3FDD;
Organisms -Eubacteria -Fungi -Metazoa
 

Family 

4.1.1.12 (12)
 
Links Enzyme (activities) 4.1.1.12
BRENDA (activities) 4.1.1.12
KEGG (pathways) 4.1.1.12
PLPMDB (PLP mutants) 4.1.1.12
 
References
 Becerra JE, Rodríguez-Díaz J, Gozalbo-Rovira R, Palomino-Schätzlein M, Zúńiga M, Monedero V, Yebra MJ (2020) Unique Microbial Catabolic Pathway for the Human Core N-Glycan Constituent Fucosyl-α-1,6-N-Acetylglucosamine-Asparagine mBio 11 e02804-19.

 Lima S, Sundararaju B, Huang C, Khristoforov R, Momany C, Phillips RS. (2009) The crystal structure of the Pseudomonas dacunhae aspartate-beta-decarboxylase dodecamer reveals an unknown oligomeric assembly for a pyridoxal-5'-phosphate-dependent enzyme J Mol Biol 388 98-108.

 Wang NC, Lee CY. (2006) Molecular cloning of the aspartate 4-decarboxylase gene from Pseudomonas sp. ATCC 19121 and characterization of the bifunctional recombinant enzyme Appl Microbiol Biotechnol 73 339-48.

 Chaillou S, Champomier-Vergčs MC, Cornet M, Crutz-Le Coq AM, Dudez AM, Martin V, Beaufils S, Darbon-Rongčre E, Bossy R, Loux V, Zagorec M. (2005) The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K. Nat Biotechnol. 23 1527-33.

 Abe, K.; Ohnishi, F.; Yagi, K.; Nakajima, T.; Higuchi, T.; Sano, M.; Machida, M.; Sarker, R.I.; Maloney, P.C. (2002) Plasmid-encoded asp operon confers a proton motive metabolic cycle catalyzed by an aspartate-alanine exchange reaction J Bacteriol 184 2906-13.

 Chen, C-C. Chou, T-L. Lee, C-Y. (2000) Cloning, expression and characterization of L-aspartate beta-decarboxylase gene from Alcaligenes faecalis CCRC 11585 J Industrial Microbiol Biotechnol 25 132-140.

Articles on 4.1.1.12
 
last changed 2017/11/28 14:21

B6db activities