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B6db activities: 4.1.1.12

4.1.1.12
Description Aspartate 4-decarboxylase.
Alternative names Aspartate-beta-decarboxylase;
Cysteine sulfinate desulfinase.
Catalyzed reaction L-aspartate = L-alanine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- Also catalyzes the decarboxylation of aminomalonate and the desulfination of 3-sulfino-L-alanine to sulfite and alanine.
-!- Formerly EC 4.1.1.10.
The only validated sequences are from bacteria. The activity occurs also in fungi and metazoa (the rat enzyme appears to be membrane-bound) but no sequences similar to the bacterial ones are found in the genomes of these organisms.
PDB 3FDD;
Organisms -Eubacteria -Fungi -Metazoa
 

Family 

4.1.1.12 (12)
 
Links Enzyme (activities) 4.1.1.12
BRENDA (activities) 4.1.1.12
KEGG (pathways) 4.1.1.12
PLPMDB (PLP mutants) 4.1.1.12
 
References
 Lima S, Sundararaju B, Huang C, Khristoforov R, Momany C, Phillips RS. (2009) The crystal structure of the Pseudomonas dacunhae aspartate-beta-decarboxylase dodecamer reveals an unknown oligomeric assembly for a pyridoxal-5'-phosphate-dependent enzyme J Mol Biol 388 98-108.

 Wang NC, Lee CY. (2006) Molecular cloning of the aspartate 4-decarboxylase gene from Pseudomonas sp. ATCC 19121 and characterization of the bifunctional recombinant enzyme Appl Microbiol Biotechnol 73 339-48.

 Chaillou S, Champomier-Vergès MC, Cornet M, Crutz-Le Coq AM, Dudez AM, Martin V, Beaufils S, Darbon-Rongère E, Bossy R, Loux V, Zagorec M. (2005) The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K. Nat Biotechnol. 23 1527-33.

 Abe, K.; Ohnishi, F.; Yagi, K.; Nakajima, T.; Higuchi, T.; Sano, M.; Machida, M.; Sarker, R.I.; Maloney, P.C. (2002) Plasmid-encoded asp operon confers a proton motive metabolic cycle catalyzed by an aspartate-alanine exchange reaction J Bacteriol 184 2906-13.

 Chen, C-C. Chou, T-L. Lee, C-Y. (2000) Cloning, expression and characterization of L-aspartate beta-decarboxylase gene from Alcaligenes faecalis CCRC 11585 J Industrial Microbiol Biotechnol 25 132-140.

Articles on 4.1.1.12
 
last changed 2010/03/11 16:20

B6db activities