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B6db activities: 4.1.1.17

4.1.1.17
Description Ornithine decarboxylase.
Alternative names ODC.
Catalyzed reaction L-ornithine = putrescine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments In mammals, ornithine decarboxylase catalyzes the rate-limiting step of the pathway leading to the production of polyamines, which play an essential role in cell proliferation.
Subfamily 1 includes enzymes that belong to the fold type III group and are mostly of eukaryotic origin.
Family 2 includes only eubacterial enzymes, beloging to the fold type I group.
Prosite PROSITE; PDOC00585; PROSITE; PDOC00685;
PDB 1ORD; 7ODC; 2TOD; 1D7K; 2PLK;
Organisms -Bacteria -Plants -Fungi -Metazoa -Human
 

Family 

4.1.1.17_1 (45) 4.1.1.17_2 (15)
 
Links Enzyme (activities) 4.1.1.17
BRENDA (activities) 4.1.1.17
KEGG (pathways) 4.1.1.17
PLPMDB (PLP mutants) 4.1.1.17
 
References
 de las Rivas B, Marcobal A, Muņoz R. (2007) Gene organization of the ornithine decarboxylase-encoding region in Morganella morganii J Appl Microbiol 102 1551-60.

 Lee J, Michael AJ, Martynowski D, Goldsmith EJ, Phillips MA. (2004) Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases J Biol Chem 282 27115-25.

 Lee JH, Son MY, Yoon MY, Choi JD, Kim YT. (2004) Isolation and characterization of ornithine decarboxylase gene from flounder (Paralichthys olivaceus) Mar Biotechnol (NY) 6 453-62.

 Shah R, Coleman CS, Mir K, Baldwin J, Van Etten JL, Grishin NV, Pegg AE, Stanley BA, Phillips MA. (2004) Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases J Biol Chem 279 35760-7.

 Lee, Y.S.; Cho, Y.D. (2001) Identification of essential active-site residues in ornithine decarboxylase of Nicotiana glutinosa decarboxylating both L-ornithine and L-lysine Biochem J 360 657-65.

 Almrud, J. J.; Oliveira, M. A.; Kern, A. D.; Grishin, N. V.; Phillips, M. A.; Hackert, M. L. (2000) Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding J Mol Biol 295 7-16..

 Guevara-Olvera, L.; Hung, C.Y.; Yu, J.J.; Cole, G.T. (2000) Sequence, expression and functional analysis of the Coccidioides immitis ODC (ornithine decarboxylase) gene Gene 25 437-48.

 Takatsuka, Y.; Yamaguchi, Y.; Ono, M.; Kamio, Y. (2000) Gene cloning and molecular characterization of lysine decarboxylase from Selenomonas ruminantium delineate its evolutionary relationship to ornithine decarboxylases from eukaryotes J Bacteriol 182 6732-41.

 Klein, R. D.; Favreau, M. A.; Alexander-Bowman, S. J.; Nulf, S. C.; Vanover, L.; Winterrowd, C. A.; Yarlett, N.; Martinez, M.; Keithly, J. S.; Zantello, M. R.; Thomas, E. M.; Geary, T. G. (1997) Haemonchus contortus: cloning and functional expression of a cDNA encoding ornithine decarboxylase and development of a screen for inhibitors Exp Parasitol 87 171-84.

 Michael, A.J.; Furze, J.M.; Rhodes M.J.; Burtin D. (1996) Molecular cloning and functional identification of a plant ornithine decarboxylase cDNA Biochem J 314 241-8.

 Niemann, G.; von Besser, H.; Walter, R. D. (1996) Panagrellus redivivus ornithine decarboxylase: structure of the gene, expression in Escherichia coli and characterization of the recombinant protein Biochem J 317 135-40.

 Momany, C.; Ernst, S.; Ghosh, R.; Chang, N. L.; Hackert, M. L. (1995) Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0 A resolution J Mol Biol 252 643-55.

 Boyle SM, Barroso L, Moore RC, Wright JM, Patel T. (1994) Primary structure of the speC gene encoding biosynthetic ornithine decarboxylase in Escherichia coli Gene 151 157-60.

 Hackert, M. L.; Carroll, D. W.; Davidson, L.; Kim, S. O.; Momany, C.; Vaaler, G. L.; Zhang, L. (1994) Sequence of ornithine decarboxylase from Lactobacillus sp. strain 30a J Bacteriol 176 7391-4.

 Fonzi, W. A. (1989) Biochemical and genetic characterization of the structure of yeast ornithine decarboxylase Biochem Biophys Res Commun 162 1409-16.

 Brabant, M.; McConlogue, L.; van Daalen Wetters, T.; Coffino, P. (1988) Mouse ornithine decarboxylase gene: cloning, structure, and expression Proc Natl Acad Sci U S A 85 2200-4.

 Phillips, M. A.; Coffino, P.; Wang, C. C. (1987) Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition J Biol Chem 262 8721-7.

Articles on 4.1.1.17
 
last changed 2009/07/07 15:56

B6db activities