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Description Sulfinoalanine decarboxylase
Alternative names Cysteine-sulfinate decarboxylase;
Cysteine sulfinic acid decarboxylase;
Catalyzed reaction 3-sulfino-L-alanine = hypotaurine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- Also acts on l-cysteate.
The enzyme is involved in the biosynthesis of taurine, a sulfur-containing amino compound that apparently functions as a cytoprotectant and occurs at high concentration (550 mM) in most animal tissues.

The sequences of sulfinoalanine decarboxylases are strictly related to those of metazoan glutamate decarboxylases (

Organisms -Metazoa -Human

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Liu P, Ding H, Christensen BM, Li J. (2012) Cysteine sulfinic acid decarboxylase activity of Aedes aegypti aspartate 1-decarboxylase: the structural basis of its substrate selectivity. Insect Biochem Mol Biol. 42 396-403.

 Liu P, Ge X, Ding H, Jiang H, Christensen BM, Li J. (2012) Role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis. J Biol Chem. 287 40898-906.

 Park, E.; Park, S.Y.; Wang, C.; Xu, J.; LaFauci, G.; Schuller-Levis, G. (2002) Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA expression in murine tissues Biochim Biophys Acta 1574 403-06.

 Tappaz, M.; Bitoun, M.; Reymond, I.; Sergeant, A. (1999) Characterization of the cDNA coding for rat brain cysteine sulfinate decarboxylase: brain and liver enzymes are identical proteins encoded by two distinct mRNAs J Neurochem 73 903-12.

 Reymond I, Sergeant A, Tappaz M. (1996) Molecular cloning and sequence analysis of the cDNA encoding rat liver cysteine sulfinate decarboxylase (CSD) Biochim Biophys Acta 1307 152-6.

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last changed 2019/03/26 11:56

B6db activities