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B6db activities: 4.1.1.53

4.1.1.53
Description Phenylalanine decarboxylase
Alternative names L-phenylalanine decarboxylase.
Catalyzed reaction L-phenylalanine = phenylethylamine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- Also acts on tyrosine and other aromatic amino acids.
Enzymes under EC 4.1.1.28 (aromatic amino acid decarboxylase) generally also catalyze this reaction.

Phenylacetaldehyde synthases (EC 4.1.1.109) are specialized decarboxylases capable of stoichiometrically coupling the decarboxylation of Phe with the further conversion of phenylethylamine to phenylacetaldehyde.

Organisms -Eubacteria -Plants -Fungi -Metazoa -Human
 

Family 

4.1.1.53 (0)
 
Links Enzyme (activities) 4.1.1.53
BRENDA (activities) 4.1.1.53
KEGG (pathways) 4.1.1.53
PLPMDB (PLP mutants) 4.1.1.53
 
References
 Torrens-Spence MP, Liu CT, Pluskal T, Chung YK, Weng JK (2018) Monoamine biosynthesis via a noncanonical calcium-activatable aromatic amino acid decarboxylase in psilocybin mushroom ACS Chem Biol 13 33433353.

 David, J. C.; Dairman, W.; Udenfriend, S. (1974) On the importance of decarboxylation in the metabolism of phenylalanine, tyrosine, and tryptophan Arch Biochem Biophys 160 561-8.

Articles on 4.1.1.53
 
last changed 2019/06/20 13:33

B6db activities