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B6db activities: 4.1.1.53

4.1.1.53
Description Phenylalanine decarboxylase.
Alternative names L-phenylalanine decarboxylase.
Catalyzed reaction L-phenylalanine = phenylethylamine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- Also acts on tyrosine and other aromatic amino acids.
Enzymes with this activity are enlisted under EC 4.1.1.28 (aromatic amino acid decarboxylase).

Phenylacetaldehyde synthase from petunia is a specialized aromatic amino acid decarboxylase that is capable of stoichiometrically coupling the decarboxylation of Phe with the further conversion of phenylethylamine to phenylacetaldehyde.

Organisms -Bacteria -Plants -Metazoa -Human
 
 
Links Enzyme (activities) 4.1.1.53
BRENDA (activities) 4.1.1.53
KEGG (pathways) 4.1.1.53
PLPMDB (PLP mutants) 4.1.1.53
 
References
 Kaminaga, Y.; Schnepp, J.;Peel G, Kish CM;Ben-Nissan G,Weiss D, Orlova I,Lavie O, Rhodes D, Wood K, Porterfield DM, Cooper AJ, Schloss JV, Pichersky E, Vainstein A, Dudareva N. (2006) Plant phenylacetaldehyde synthase is a bifunctional homotetrameric enzyme that catalyzes phenylalanine decarboxylation and oxidation J. Biol. Chem. 281 23357-66.

 David, J. C.; Dairman, W.; Udenfriend, S. (1974) On the importance of decarboxylation in the metabolism of phenylalanine, tyrosine, and tryptophan Arch Biochem Biophys 160 561-8.

Articles on 4.1.1.53
 
last changed 2009/06/18 16:10

B6db activities