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4.1.1.64 |
Description |
2,2-dialkylglycine decarboxylase (pyruvate) |
Alternative names |
alpha-dialkylamino acid transaminase;
L-alanine-alpha-ketobutyrate aminotransferase; DGD. |
Catalyzed reaction |
2,2-dialkylglycine + pyruvate = dialkyl ketone + CO(2) + L-alanine. |
Cofactor |
Pyridoxal-phosphate. |
Comments |
-!- Acts on 2-amino-2-methylpropanoate (i.e. 2-methylalanine), 2-amino-2-methylbutanoate and 1-aminocyclopentanecarboxylate. |
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Mechanistically, dialkylglycine decarboxylase is a very peculiar PLP-dependent enzyme, which catalyzes both decarboxylation and transamination in its normal catalytic cycle.
Enzymes with this activity occur sporadically in bacteria and fungi, but their biological role is unclear. |
Prosite |
PROSITE; PDOC00519; |
PDB |
1D7S; 1D7V; |
Organisms |
-Eubacteria -Fungi |
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Family |
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Links |
Enzyme (activities) 4.1.1.64
BRENDA (activities) 4.1.1.64
KEGG (pathways) 4.1.1.64
PLPMDB (PLP mutants) 4.1.1.64
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References |
Adachi, K.; Nelson, G.H.; Peoples, K.A.; DeZwaan, T.M.; Skalchunes, A.R.; Heiniger, R.W.; Shuster, J.R.; Hamer, L.; Tanzer, M.M. (2003) Sequence analysis and functional characterization of the dialkylglycine decarboxylase gene DGD1 from Mycosphaerella graminicola Curr genet 43 358-63. Toney, M. D.; Hohenester, E.; Cowan, S. W.; Jansonius, J. N. (1993) Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites Science 261 756-9. Keller, J. W.; Baurick, K. B.; Rutt, G. C.; O'Malley, M. V.; Sonafrank, N. L.; Reynolds, R. A.; Ebbesson, L. O.; Vajdos, F. F. (1990) Pseudomonas cepacia 2,2-dialkylglycine decarboxylase. Sequence and expression in Escherichia coli of structural and repressor genes J Biol Chem 265 5531-9. Articles on 4.1.1.64 |
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last changed |
2019/06/21 13:11 |
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