B6db activities : 4_1_1

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	4.1.1.64
Description	2,2-dialkylglycine decarboxylase (pyruvate).
Alternative names	alpha-dialkylamino acid transaminase. L-alanine-alpha-ketobutyrate aminotransferase. DGD
Catalyzed reaction	2,2-dialkylglycine + pyruvate = dialkyl ketone + CO(2) + L-alanine.
Cofactor	Pyridoxal-phosphate.
Comments	-!- Acts on 2-amino-2-methylpropanoate (i.e. 2-methylalanine), 2-amino-2-methylbutanoate and 1-aminocyclopentanecarboxylate.
	Mechanistically, dialkylglycine decarboxylase is a very peculiar PLP-dependent enzyme, which catalyzes both decarboxylation and transamination in its normal catalytic cycle. Enzymes with this activity occur sporadically in bacteria and fungi, but their biological role is unclear.
Prosite	PROSITE; PDOC00519;
PDB	1D7S; 1D7V;
Organisms	-Bacteria -Fungi
Family	4.1.1.64 (12)

Links	Enzyme (activities) 4.1.1.64 BRENDA (activities) 4.1.1.64 KEGG (pathways) 4.1.1.64 PLPMDB (PLP mutants) 4.1.1.64

References	Adachi, K.; Nelson, G.H.; Peoples, K.A.; DeZwaan, T.M.; Skalchunes, A.R.; Heiniger, R.W.; Shuster, J.R.; Hamer, L.; Tanzer, M.M. (2003) Sequence analysis and functional characterization of the dialkylglycine decarboxylase gene DGD1 from Mycosphaerella graminicola Curr genet 43 358-63. Toney, M. D.; Hohenester, E.; Cowan, S. W.; Jansonius, J. N. (1993) Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites Science 261 756-9.. Keller, J. W.; Baurick, K. B.; Rutt, G. C.; O'Malley, M. V.; Sonafrank, N. L.; Reynolds, R. A.; Ebbesson, L. O.; Vajdos, F. F. (1990) Pseudomonas cepacia 2,2-dialkylglycine decarboxylase. Sequence and expression in Escherichia coli of structural and repressor genes J Biol Chem 265 5531-9.. Articles on 4.1.1.64

last changed	2008/07/01 12:58

Family