4.1.1.81
Description	Threonine-phosphate decarboxylase
Alternative names	L-threonine-O-3-phosphate decarboxylase; CobD.
Catalyzed reaction	L-threonine O-3-phosphate = (R)-1-aminopropan-2-ol phosphate + CO(2).
Cofactor	Pyridoxal-phosphate
Comments	This enzyme is unable to decarboxylate the D-isomer of threonine O-3-phosphate. The product of this reaction, (R)-1-aminopropan-2-yl phosphate, is the substrate of EC 6.3.1.10, adenosylcobinamide phosphate synthase, which converts adenosylcobyric acid into adenosylcobinamide phosphate in the anaerobic cobalamin biosynthesis pathway.
	In Salmonella enterica, this enzyme is coded by the CobD gene, and its role in cobalamin biosynthesis has been established. Structurally the Salmonella protein shows a strong similarity to histidinol phosphate aminotransferase (2.6.1.9).
PDB	1LKC;
Organisms	-Eubacteria
Links	Enzyme (activities) 4.1.1.81 BRENDA (activities) 4.1.1.81 KEGG (pathways) 4.1.1.81 PLPMDB (PLP mutants) 4.1.1.81
References	Articles on 4.1.1.81
last changed	2019/06/19 09:10