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B6db activities: 4.1.1.81

4.1.1.81
Description Threonine-phosphate decarboxylase
Alternative names L-threonine-O-3-phosphate decarboxylase;
CobD.
Catalyzed reaction L-threonine O-3-phosphate = (R)-1-aminopropan-2-ol phosphate + CO(2).
Cofactor Pyridoxal-phosphate
Comments This enzyme is unable to decarboxylate the D-isomer of threonine O-3-phosphate.
The product of this reaction, (R)-1-aminopropan-2-yl phosphate, is the substrate of EC 6.3.1.10, adenosylcobinamide phosphate synthase, which converts adenosylcobyric acid into adenosylcobinamide phosphate in the anaerobic cobalamin biosynthesis pathway.
In Salmonella enterica, this enzyme is coded by the CobD gene, and its role in cobalamin biosynthesis has been established. Structurally the Salmonella protein shows a strong similarity to histidinol phosphate aminotransferase (2.6.1.9).
PDB 1LKC;
Organisms -Eubacteria
 
 
Links Enzyme (activities) 4.1.1.81
BRENDA (activities) 4.1.1.81
KEGG (pathways) 4.1.1.81
PLPMDB (PLP mutants) 4.1.1.81
 
References Articles on 4.1.1.81
 
last changed 2019/06/19 09:10

B6db activities