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B6db activities: 4.1.1.86

4.1.1.86
Description Diaminobutyrate decarboxylase
Alternative names DABA decarboxylase;
L-2,4-diaminobutyrate decarboxylase.
Catalyzed reaction L-2,4-diaminobutyrate = 1,3-diaminopropane + CO(2).
Cofactor Pyridoxal-phosphate; divalent metal ion
Comments -!- N(4)-acetyl-L-2,4-diaminobutanoate, 2,3-diaminopropanoate, ornithine and lysine are not substrates.
-!-In Acinetobacter baumannii it is cotranscribed with the neighboring dat gene that encodes EC 2.6.1.76, which can supply the substrate for the decarboxylase.
PDB 2QMA;
Organisms -Bacteria
 

Family 

4.1.1.86 (13)
 
Links Enzyme (activities) 4.1.1.86
BRENDA (activities) 4.1.1.86
KEGG (pathways) 4.1.1.86
PLPMDB (PLP mutants) 4.1.1.86
 
References
 Yamamoto, S.; Mutoh, N.; Tsuzuki, D.; Ikai, H.; Nakao, H.; Shinoda, S.; Narimatsu, S.; Miyoshi, S.I. (2000) Cloning and characterization of the ddc homolog encoding L-2,4-diaminobutyrate decarboxylase in Enterobacter aerogenes Biol Pharm Bull 23 649-53.

 Ikai, H.; Yamamoto, S. (1996) Sequence analysis of the gene encoding a novel L-2,4-diaminobutyrate decarboxylase of Acinetobacter baumannii: similarity to the group II amino acid decarboxylases Arch Microbiol 166 128-31.

Articles on 4.1.1.86
 
last changed 2009/07/10 16:42

B6db activities