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B6db activities: 4.1.2.27

4.1.2.27
Description Sphinganine-1-phosphate aldolase.
Alternative names Sphingosine-1-phosphate lyase;
Sphingosine phosphate lyase.
Catalyzed reaction Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.
Cofactor Pyridoxal-phosphate.
The enzyme controls the concentration of sphingosine 1-phosphate, a key sphingolipid second messenger involved in the regulation of cell proliferation, motility, invasiveness, and apoptosis.
PDB 3MAD; 3MAF; 3MBB;
Organisms -Plants -Fungi -Metazoa -Human
 

Family 

4.1.2.27 (24)
 
Links Enzyme (activities) 4.1.2.27
BRENDA (activities) 4.1.2.27
KEGG (pathways) 4.1.2.27
PLPMDB (PLP mutants) 4.1.2.27
 
References
 Ikeda M, Kihara A, Kariya Y, Lee YM, Igarashi Y. (2005) Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme Biochem Biophys Res Commun 329 474-9.

 Herr, D.R.; Fyrst, H.; Phan, V.; Heinecke, K.; Georges, R.; Harris, G.L.; Saba, J.D. (2003) Sply regulation of sphingolipid signaling molecules is essential for Drosophila development Development 130 2443-53.

 Mendel, J.; Heinecke, K.; Fyrst, H.; Saba, J.D. (2003) Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans J Biol Chem 278 22341-9.

 Li, G.; Foote, C.; Alexander, S.; Alexander, H. (2001) Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum Development 128 3473-83.

 Van Veldhoven, P.P.; Gijsbers, S.; Mannaerts, G.P.; Vermeesch, J.R.; Brys, V. (2000) Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1) Biochim Biophys Acta 1487 128-34.

 Zhou, J.; Saba, J. D. (1998) Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast Biochem Biophys Res Commun 242 502-7.

 Saba, J.D.; Nara F.; Bielawska, A.; Garrett, S.; Hannun, Y.A. (1997) The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem 272 26087-90.

Articles on 4.1.2.27
 
last changed 2014/03/20 12:24

B6db activities