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Description 4-amino-4-deoxychorismate lyase
Alternative names 4-amino-4-deoxychorismate pyruvate-lyase;
Aminodeoxychorismate lyase;
ADC lyase.
Catalyzed reaction 4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate
Cofactor Pyridoxal-phosphate.
Comments Forms part of the folate biosynthesis pathway.
Acts on 4-amino-4-deoxychorismate, the product of EC, aminodeoxychorismate synthase, to form p-aminobenzoate.
At least three different subgroups of enzymes with this activity appear to exist. These enzymes all belong to the fold-type IV group, but show very limited sequence similarity to each other.
PDB 1ET0; 2Y4R; 4K6N;
Organisms -Eubacteria -Plants -Fungi


Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Dai YN1, Chi CB, Zhou K, Cheng W, Jiang YL, Ren YM, Ruan K, Chen Y, Zhou CZ. (2013) Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase J Biol Chem 288 22985-92.

 Magnani G, Lomazzi M, Peracchi A. (2013) Completing the folate biosynthesis pathway in Plasmodium falciparum: p-aminobenzoate is produced by a highly divergent promiscuous aminodeoxychorismate lyase. Biochem J. 455 149-55.

 Chim N, Habel JE, Johnston JM, Krieger I, Miallau L, Sankaranarayanan R, Morse RP, Bruning J, Swanson S, Kim H, Kim CY, Li H, Bulloch EM, Payne RJ, Manos-Turvey A, Hung LW, Baker EN, Lott JS, James MN, Terwilliger TC, Eisenberg DS, Sacchettini JC, Goulding CW. (2011) The TB Structural Genomics Consortium: a decade of progress Tuberculosis (Edinb) 91 155-72.

 O'Rourke PE1, Eadsforth TC, Fyfe PK, Shepherd SM, Hunter WN. (2011) Pseudomonas aeruginosa 4-amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme PLoS One 6 e24158.

 Schadt HS, Schadt S, Oldach F, Süssmuth RD (2009) 2-Amino-2-deoxyisochorismate is a key intermediate in Bacillus subtilis p-aminobenzoic acid biosynthesis. J Am Chem Soc 131 3481-3.

 Zhang Y, Bai L, Deng Z. (2009) Functional characterization of the first two actinomycete 4-amino-4-deoxychorismate lyase genes Microbiology 155 2450-9.

 Botet J, Mateos L, Revuelta JL, Santos MA. (2007) A chemogenomic screening of sulfanilamide-hypersensitive Saccharomyces cerevisiae mutants uncovers ABZ2, the gene encoding a fungal aminodeoxychorismate lyase Eukaryot Cell 6 2102-11.

 Nakai, T.; Mizutani, H.; Miyahara, I.; Hirotsu, K.; Takeda, S.; Jhee, K. H.; Yoshimura, T.; Esaki, N. (2000) Three-dimensional structure of 4-amino-4-deoxychorismate lyase from Escherichia coli J Biochem (Tokyo) 128 29-38.

 Green, J. M.; Nichols, B. P. (1991) p-Aminobenzoate biosynthesis in Escherichia coli. Purification of aminodeoxychorismate lyase and cloning of pabC J Biol Chem 266 12971-5.

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last changed 2019/06/20 13:05

B6db activities