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B6db activities:
Description Tyrosine phenol-lyase
Alternative names Beta-tyrosinase;
Catalyzed reaction L-tyrosine + H(2)O = phenol + pyruvate + NH(3).
Cofactor Pyridoxal-phosphate.
Comments -!- Also slowly catalyzes pyruvate formation from D-tyrosine, S-methyl- L-cysteine, L-cysteine, L-serine and D-serine.
Prosite PROSITE; PDOC00667;
Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Zheng RC, Tang XL, Suo H, Feng LL, Liu X, Yang J, Zheng YG (2018) Biochemical characterization of a novel tyrosine phenol-lyase from Fusobacterium nucleatum for highly efficient biosynthesis of l-DOPA Enzyme Microb Technol 112 88-93.

 Phillips RS, Demidkina TV, Faleev NG. (2003) Structure and mechanism of tryptophan indole-lyase and tyrosine phenol-lyase Biochim Biophys Acta 1647 167-72.

 Lee, S. G.; Hong, S. P.; Choi, Y. H.; Chung, Y. J.; Sung, M. H. (1997) Thermostable tyrosine phenol-lyase of Symbiobacterium sp. SC-1: gene cloning, sequence determination, and overproduction in Escherichia coli Protein Expr Purif 11 263-70.

 Sundararaju, B.; Antson, A. A.; Phillips, R. S.; Demidkina, T. V.; Barbolina, M. V.; Gollnick, P.; Dodson, G. G.; Wilson, K. S. (1997) The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4'-hydroxyphenyl)propionic acid, together with site- directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity Biochemistry 36 6502-10.

 Iwamori, S.; Oikawa, T.; Ishiwata, K.; Makiguchi, N. (1992) Cloning and expression of the Erwinia herbicola tyrosine phenol-lyase gene in Escherichia coli Biotechnol Appl Biochem 16 77-85.

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last changed 2019/06/20 12:58

B6db activities