B6db activities : 4_1_99

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	4.1.99.2
Description	Tyrosine phenol-lyase.
Alternative names	Beta-tyrosinase.
Catalyzed reaction	L-tyrosine + H(2)O = phenol + pyruvate + NH(3).
Cofactor	Pyridoxal-phosphate.
Comments	-!- Also slowly catalyzes pyruvate formation from D-tyrosine, S-methyl- L-cysteine, L-cysteine, L-serine and D-serine.
Prosite	PROSITE; PDOC00667;
PDB	1TPL; 2TPL;
Organisms	-Bacteria
Family	4.1.99.2 (10)

Links	Enzyme (activities) 4.1.99.2 BRENDA (activities) 4.1.99.2 KEGG (pathways) 4.1.99.2 PLPMDB (PLP mutants) 4.1.99.2

References	Phillips RS, Demidkina TV, Faleev NG. (2003) Structure and mechanism of tryptophan indole-lyase and tyrosine phenol-lyase Biochim Biophys Acta 1647 167-72. Lee, S. G.; Hong, S. P.; Choi, Y. H.; Chung, Y. J.; Sung, M. H. (1997) Thermostable tyrosine phenol-lyase of Symbiobacterium sp. SC-1: gene cloning, sequence determination, and overproduction in Escherichia coli Protein Expr Purif 11 263-70.. Sundararaju, B.; Antson, A. A.; Phillips, R. S.; Demidkina, T. V.; Barbolina, M. V.; Gollnick, P.; Dodson, G. G.; Wilson, K. S. (1997) The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4'-hydroxyphenyl)propionic acid, together with site- directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity Biochemistry 36 6502-10.. Iwamori, S.; Oikawa, T.; Ishiwata, K.; Makiguchi, N. (1992) Cloning and expression of the Erwinia herbicola tyrosine phenol-lyase gene in Escherichia coli Biotechnol Appl Biochem 16 77-85.. Articles on 4.1.99.2

last changed	2007/09/20 18:48

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