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B6db activities:
Description Tyrosine phenol-lyase.
Alternative names Beta-tyrosinase;
Catalyzed reaction L-tyrosine + H(2)O = phenol + pyruvate + NH(3).
Cofactor Pyridoxal-phosphate.
Comments -!- Also slowly catalyzes pyruvate formation from D-tyrosine, S-methyl- L-cysteine, L-cysteine, L-serine and D-serine.
Prosite PROSITE; PDOC00667;
Organisms -Bacteria

Family (10)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Phillips RS, Demidkina TV, Faleev NG. (2003) Structure and mechanism of tryptophan indole-lyase and tyrosine phenol-lyase Biochim Biophys Acta 1647 167-72.

 Lee, S. G.; Hong, S. P.; Choi, Y. H.; Chung, Y. J.; Sung, M. H. (1997) Thermostable tyrosine phenol-lyase of Symbiobacterium sp. SC-1: gene cloning, sequence determination, and overproduction in Escherichia coli Protein Expr Purif 11 263-70.

 Sundararaju, B.; Antson, A. A.; Phillips, R. S.; Demidkina, T. V.; Barbolina, M. V.; Gollnick, P.; Dodson, G. G.; Wilson, K. S. (1997) The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4'-hydroxyphenyl)propionic acid, together with site- directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity Biochemistry 36 6502-10.

 Iwamori, S.; Oikawa, T.; Ishiwata, K.; Makiguchi, N. (1992) Cloning and expression of the Erwinia herbicola tyrosine phenol-lyase gene in Escherichia coli Biotechnol Appl Biochem 16 77-85.

Articles on
last changed 2009/06/23 09:44

B6db activities