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B6db activities: 4.2.1.144

4.2.1.144
Description 3-amino-5-hydroxybenzoic acid synthase
Alternative names 3-amino-5-hydroxybenzoate synthase;
AHBA synthase
Catalyzed reaction 5-amino-5-deoxy-3-dehydroshikimate <=> 3-amino-5-hydroxybenzoate + H(2)O
Cofactor Pyridoxal-phosphate.
Comments The enzyme from the bacterium Amycolatopsis mediterranei participates in the pathway for rifamycin B biosynthesis. The enzyme also functions as a transaminase earlier in the pathway, producing UDP-alpha-D-kanosamine.
3-amino-5-hydroxybenzoic acid (AHBA) serves as starter for the assembly of the polyketide backbone of several antibiotics, such as rifamycin and ansamycin.
PDB 1B9H;
Organisms -Eubacteria -Archea
 

Family 

4.2.1.144 (0)
 
Links Enzyme (activities) 4.2.1.144
BRENDA (activities) 4.2.1.144
KEGG (pathways) 4.2.1.144
PLPMDB (PLP mutants) 4.2.1.144
 
References Articles on 4.2.1.144
 
last changed 2014/02/19 11:43

B6db activities