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4.2.1.144 |
Description |
3-amino-5-hydroxybenzoic acid synthase |
Alternative names |
3-amino-5-hydroxybenzoate synthase;
AHBA synthase |
Catalyzed reaction |
5-amino-5-deoxy-3-dehydroshikimate <=> 3-amino-5-hydroxybenzoate + H(2)O |
Cofactor |
Pyridoxal-phosphate. |
Comments |
The enzyme from the bacterium Amycolatopsis mediterranei participates in the pathway for rifamycin B biosynthesis.
The enzyme also functions as a transaminase earlier in the pathway, producing UDP-alpha-D-kanosamine. |
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3-amino-5-hydroxybenzoic acid (AHBA) serves as starter for the assembly of the polyketide backbone of several antibiotics, such as rifamycin and ansamycin. |
PDB |
1B9H; |
Organisms |
-Eubacteria -Archea |
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Family |
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Links |
Enzyme (activities) 4.2.1.144
BRENDA (activities) 4.2.1.144
KEGG (pathways) 4.2.1.144
PLPMDB (PLP mutants) 4.2.1.144
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References |
He W, Wu L, Gao Q, Du Y, Wang Y.
(2006) Identification of AHBA biosynthetic genes related to geldanamycin biosynthesis in Streptomyces hygroscopicus 17997 Curr Microbiol 52 197-203. Yu, T.W., Bai, L., Clade, D., Hoffmann, D., Toelzer, S., Trinh, K.Q., Xu, J., Moss, S.J., Leistner, E., Floss, H.G.
(2002) The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum Proc Natl Acad Sci U S A. 99 7968-7973. Eads, J.C., Beeby, M., Scapin, G., Yu, T.W.; Floss, H.G. (1999) Crystal structure of 3-amino-5-hydroxybenzoic acid (AHBA) synthase Biochemistry 38 9840-9849. Articles on 4.2.1.144 |
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last changed |
2014/02/19 11:43 |
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