B6db activities : 4_2_1

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	4.2.1.144
Description	3-amino-5-hydroxybenzoic acid synthase
Alternative names	3-amino-5-hydroxybenzoate synthase; AHBA synthase
Catalyzed reaction	5-amino-5-deoxy-3-dehydroshikimate <=> 3-amino-5-hydroxybenzoate + H(2)O
Cofactor	Pyridoxal-phosphate.
Comments	The enzyme from the bacterium Amycolatopsis mediterranei participates in the pathway for rifamycin B biosynthesis. The enzyme also functions as a transaminase earlier in the pathway, producing UDP-alpha-D-kanosamine.
	3-amino-5-hydroxybenzoic acid (AHBA) serves as starter for the assembly of the polyketide backbone of several antibiotics, such as rifamycin and ansamycin.
PDB	1B9H;
Organisms	-Eubacteria -Archea
Family	4.2.1.144 (0)

Links	Enzyme (activities) 4.2.1.144 BRENDA (activities) 4.2.1.144 KEGG (pathways) 4.2.1.144 PLPMDB (PLP mutants) 4.2.1.144

References	He W, Wu L, Gao Q, Du Y, Wang Y. (2006) Identification of AHBA biosynthetic genes related to geldanamycin biosynthesis in Streptomyces hygroscopicus 17997 Curr Microbiol 52 197-203. Yu, T.W., Bai, L., Clade, D., Hoffmann, D., Toelzer, S., Trinh, K.Q., Xu, J., Moss, S.J., Leistner, E., Floss, H.G. (2002) The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum Proc Natl Acad Sci U S A. 99 7968-7973. Eads, J.C., Beeby, M., Scapin, G., Yu, T.W.; Floss, H.G. (1999) Crystal structure of 3-amino-5-hydroxybenzoic acid (AHBA) synthase Biochemistry 38 9840-9849. Articles on 4.2.1.144

last changed	2014/02/19 11:43

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