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4.2.1.144 |
Description |
3-amino-5-hydroxybenzoic acid synthase |
Alternative names |
3-amino-5-hydroxybenzoate synthase;
AHBA synthase |
Catalyzed reaction |
5-amino-5-deoxy-3-dehydroshikimate <=> 3-amino-5-hydroxybenzoate + H(2)O |
Cofactor |
Pyridoxal-phosphate. |
Comments |
The enzyme from the bacterium Amycolatopsis mediterranei participates in the pathway for rifamycin B biosynthesis.
The enzyme also functions as a transaminase earlier in the pathway, producing UDP-alpha-D-kanosamine. |
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3-amino-5-hydroxybenzoic acid (AHBA) serves as starter for the assembly of the polyketide backbone of several antibiotics, such as rifamycin and ansamycin. |
PDB |
1B9H; |
Organisms |
-Eubacteria -Archea |
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Family |
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Links |
Enzyme (activities) 4.2.1.144
BRENDA (activities) 4.2.1.144
KEGG (pathways) 4.2.1.144
PLPMDB (PLP mutants) 4.2.1.144
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References |
Articles on 4.2.1.144 |
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last changed |
2014/02/19 11:43 |
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