B6db activities : 4_2_1

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	4.2.1.144
Description	3-amino-5-hydroxybenzoic acid synthase
Alternative names	3-amino-5-hydroxybenzoate synthase; AHBA synthase
Catalyzed reaction	5-amino-5-deoxy-3-dehydroshikimate <=> 3-amino-5-hydroxybenzoate + H(2)O
Cofactor	Pyridoxal-phosphate.
Comments	The enzyme from the bacterium Amycolatopsis mediterranei participates in the pathway for rifamycin B biosynthesis. The enzyme also functions as a transaminase earlier in the pathway, producing UDP-alpha-D-kanosamine.
	3-amino-5-hydroxybenzoic acid (AHBA) serves as starter for the assembly of the polyketide backbone of several antibiotics, such as rifamycin and ansamycin.
PDB	1B9H;
Organisms	-Eubacteria -Archea
Family	4.2.1.144 (0)

Links	Enzyme (activities) 4.2.1.144 BRENDA (activities) 4.2.1.144 KEGG (pathways) 4.2.1.144 PLPMDB (PLP mutants) 4.2.1.144

References	Articles on 4.2.1.144

last changed	2014/02/19 11:43

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