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B6db activities: 4.2.1.144

4.2.1.144
Description 3-amino-5-hydroxybenzoic acid synthase
Alternative names 3-amino-5-hydroxybenzoate synthase;
AHBA synthase
Catalyzed reaction 5-amino-5-deoxy-3-dehydroshikimate <=> 3-amino-5-hydroxybenzoate + H(2)O
Cofactor Pyridoxal-phosphate.
Comments The enzyme from the bacterium Amycolatopsis mediterranei participates in the pathway for rifamycin B biosynthesis. The enzyme also functions as a transaminase earlier in the pathway, producing UDP-alpha-D-kanosamine.
3-amino-5-hydroxybenzoic acid (AHBA) serves as starter for the assembly of the polyketide backbone of several antibiotics, such as rifamycin and ansamycin.
PDB 1B9H;
Organisms -Eubacteria -Archea
 

Family 

4.2.1.144 (7)
 
Links Enzyme (activities) 4.2.1.144
BRENDA (activities) 4.2.1.144
KEGG (pathways) 4.2.1.144
PLPMDB (PLP mutants) 4.2.1.144
 
References
 He W, Wu L, Gao Q, Du Y, Wang Y. (2006) Identification of AHBA biosynthetic genes related to geldanamycin biosynthesis in Streptomyces hygroscopicus 17997 Curr Microbiol 52 197-203.

 Yu, T.W., Bai, L., Clade, D., Hoffmann, D., Toelzer, S., Trinh, K.Q., Xu, J., Moss, S.J., Leistner, E., Floss, H.G. (2002) The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum Proc Natl Acad Sci U S A. 99 7968-7973.

 Eads, J.C., Beeby, M., Scapin, G., Yu, T.W.; Floss, H.G. (1999) Crystal structure of 3-amino-5-hydroxybenzoic acid (AHBA) synthase Biochemistry 38 9840-9849.

Articles on 4.2.1.144
 
last changed 2014/02/19 11:43

B6db activities