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B6db activities:
Description Tryptophan synthase
Alternative names Tryptophan synthetase;
Tryptophan desmolase.
Catalyzed reaction L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O.
Cofactor Pyridoxal-phosphate.
Comments -!- Also catalyzes the conversion of indoleglycerol phosphate into indole and glyceraldehyde phosphate (alpha reaction) and of serine and indole into tryptophan and water (beta reaction).
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC, EC, EC, and EC
Prosite PROSITE; PDOC00151; PROSITE; PDOC00152;
Organisms -Eubacteria -Archea -Plants -Fungi

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Buller AR, Brinkmann-Chen S, Romney DK, Herger M, Murciano-Calles J, Arnold FH (2015) Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation Proc Natl Acad Sci U S A 112 14599-604.

 Mitsuya D, Tanaka S, Matsumura H, Urano N, Takano K, Ogasahara K, Takehira M, Yutani K, Ishida M. (2014) Strategy for cold adaptation of the tryptophan synthase α subunit from the psychrophile Shewanella frigidimarina K14-2: crystal structure and physicochemical properties J Biochem 155 73-82.

 Shen H, Yang Y, Wang F, Zhang Y, Ye N, Xu S, Wang H. (2009) Characterization of the putative tryptophan synthase beta-subunit from Mycobacterium tuberculosis Acta Biochim Biophys Sin (Shanghai) 41 379-88.

 Ogasahara K1, Ishida M, Yutani K. (2003) Stimulated interaction between and subunits of tryptophan synthase from hyperthermophile enhances its thermal stability J Biol Chem 278 8922-8.

 Fehlner-Gardiner C, Roshick C, Carlson JH, Hughes S, Belland RJ, Caldwell HD, McClarty G. (2002) Molecular basis defining human Chlamydia trachomatis tissue tropism. A possible role for tryptophan synthase J Biol Chem 277 26893-903.

 Xie, G.; Forst, C.; Bonner, C.; Jensen, R.A. (2002) Significance of two distinct types of tryptophan synthase beta chain in Bacteria, Archaea and higher plants Genome Biol 3 R-0004.

 Tang, X.F.; Ezaki, S.; Atomi, H.; Imanaka, T. (2000) Biochemical analysis of a thermostable tryptophan synthase from a hyperthermophilic archaeon Eur J Biochem 267 6369-77.

 Kisaka, H.; Kisaka, M.; Lee, H. Y.; Kameya, T. (1998) Isolation of a cDNA for tryptophan synthase beta from rice and studies of its expression in a 5-methyltryptophan-resistant mutant of rice Plant Mol Biol 38 875-8.

 Lam, W.L.; Cohen, A.; Tsouluhas, D.; Doolittle, W.F. (1990) Genes for tryptophan biosynthesis in the archaebacterium Haloferax volcanii Proc Natl Acad Sci U S A 87 6614-8.

 Berlyn, M.B.; Last, R.L.; Fink, G.R. (1989) A gene encoding the tryptophan synthase beta subunit of Arabidopsis thaliana Proc Natl Acad Sci U S A 86 4604-8.

 Crawford, I.P.; Eberly, L. (1989) DNA sequence of the tryptophan synthase genes of Pseudomonas putida Biochimie 71 521-31.

 Hyde, C. C.; Ahmed, S. A.; Padlan, E. A.; Miles, E. W.; Davies, D. R. (1988) Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium J Biol Chem 263 17857-71.

 Zalkin H, Yanofsky C. (1982) Yeast gene TRP5: structure, function, regulation J Biol Chem 257 1491-500.

 Crawford IP, Nichols BP, Yanofsky C. (1980) Nucleotide sequence of the trpB gene in Escherichia coli and Salmonella typhimurium J Mol Biol 142 489-502.

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last changed 2019/06/21 13:15

B6db activities