B6db activities : 4_2_3

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	4.2.3.1
Description	Threonine synthase.
Catalyzed reaction	O-phospho-L-homoserine + H(2)O = L-threonine + phosphate.
Cofactor	Pyridoxal-phosphate.
Comments	-!- Formerly EC 4.2.99.2.
	This enzyme participates in glycine, serine and threonine metabolism. Threonine synthase is also a main regulatory control point of methionine synthesis in several plants, as it competes with plastidial cystathionine gamma-synthase (EC 2.5.1.48), for their common substrate O-phosphohomoserine.
Prosite	PROSITE; PDOC00149;
PDB	1KL7; 1E5X; 1UIN; 1UIM;
Organisms	-Bacteria -Archea -Plants -Fungi
Family	4.2.3.1 (41)

Links	Enzyme (activities) 4.2.3.1 BRENDA (activities) 4.2.3.1 KEGG (pathways) 4.2.3.1 PLPMDB (PLP mutants) 4.2.3.1

References	Covarrubias AS, Högbom M, Bergfors T, Carroll P, Mannerstedt K, Oscarson S, Parish T, Jones TA, Mowbray SL. (2008) Structural, biochemical, and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis J Mol Biol 381 622-33. Tang DW, Li LF, Yu YM, Liu XY, Su XD, Zhao X, Liang YH. (2007) Preparation, crystallization and preliminary X-ray analysis of threonine synthase from Streptococcus mutans Protein Pept Lett 14 836-8. Omi, R.; Goto, M.; Miyahara, I.; Mizuguchi, H.; Hayashi, H.; Kagamiyama, H.; Hirotsu, K. (2003) Crystal structures of threonine synthase from Thermus thermophilus HB8: conformational change, substrate recognition, and mechanism J Biol Chem 278 46035-45.. Garrido-Franco, M.; Ehlert, S.; Messerschmidt, A.; Marinkovic, S.; Huber, R.; Laber, B.; Bourenkov, G. P.; Clausen, T. (2002) Structure and function of threonine synthase from yeast J Biol Chem 277 12396-405. Curien, G.; Dumas, R.; Ravanel, S.; Douce, R. (1996) Characterization of an Arabidopsis thaliana cDNA encoding an S- adenosylmethionine-sensitive threonine synthase. Threonine synthase from higher plants FEBS Lett 390 85-90.. Malumbres, M.; Mateos, L. M.; Guerrero, C.; Martin, J. F. (1995) Molecular cloning of the hom-thrC-thrB cluster from Bacillus sp. ULM1: expression of the thrC gene in Escherichia coli and corynebacteria, and evolutionary relationships of the threonine genes Folia Microbiol 40 595-606. Malumbres, M.; Mateos, L. M.; Lumbreras, M. A.; Guerrero, C.; Martin, J. F. (1994) Analysis and expression of the thrC gene of Brevibacterium lactofermentum and characterization of the encoded threonine synthase Appl Environ Microbiol 60 2209-19. Clepet, C.; Borne, F.; Krishnapillai, V.; Baird, C.; Patte, J. C.; Cami, B. (1992) Isolation, organization and expression of the Pseudomonas aeruginosa threonine genes Mol Microbiol 6 3109-19.. Parsot, C.; Cossart, P.; Saint-Girons, I.; Cohen, G. N. (1983) Nucleotide sequence of thrC and of the transcription termination region of the threonine operon in Escherichia coli K12 Nucleic Acids Res 11 7331-45. Articles on 4.2.3.1

last changed	2008/03/11 18:37

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