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4.2.3.134 |
Description |
5-phosphonooxy-L-lysine phospho-lyase |
Alternative names |
5-phosphohydroxy-L-lysine ammoniophospholyase; (5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating;(S)-2-amino-6-oxohexanoate-forming)
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Catalyzed reaction |
(5R)-5-phosphonooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH3 + phosphate |
Cofactor |
Pyridoxal-phosphate. |
Comments |
A pyridoxal-phosphate protein. Has no activity with phosphoethanolamine (cf. EC 4.2.3.2, ethanolamine-phosphate phospho-lyase). |
Organisms |
-Metazoa -Human |
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Family |
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Links |
Enzyme (activities) 4.2.3.134
BRENDA (activities) 4.2.3.134
KEGG (pathways) 4.2.3.134
PLPMDB (PLP mutants) 4.2.3.134
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References |
Veiga-da-Cunha, M., Hadi, F., Balligand, T., Stroobant, V. and Van Schaftingen, E. (2012) Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. J. Biol. Chem. 287 7246-7255. Tsai, C.H. and Henderson, L.M. (1974) Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase. J. Biol. Chem. 249 5784-5789. Articles on 4.2.3.134 |
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last changed |
2017/06/23 13:03 |
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