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B6db activities:
Description Cystathionine gamma-lyase
Alternative names Homoserine deaminase;
Homoserine dehydratase;
Cystine desulfhydrase;
Cysteine desulfhydrase (ambiguous);
Catalyzed reaction L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate.
Cofactor Pyridoxal-phosphate.
Comments -!- Also catalyzes elimination reactions of L-homoserine to form H(2)O, NH(3) and 2-oxobutanoate, of L-cystine, producing thiocysteine, pyruvate and NH(3), and of L-cysteine producing pyruvate, NH(3) and H(2)S.
-!- Formerly EC
Often, these enzymes also exhibit gamma-synthase activity (EC, making their exact classification difficult. Indeed, the gene from H. pylori has recently been assigned a gamma-synthase function.

The enzyme from Lactococcus lactis can carry out both an alpha,gamma-elimination and an alpha,beta-elimination reactions on cystathionine, hence in some database entries this gene is classified as cystathionine beta-lyase (EC

Diseases Cystathioninuria
Prosite PROSITE; PDOC00677;
Organisms -Eubacteria -Plants -Fungi -Metazoa -Human
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2019/06/20 13:02

B6db activities