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4.4.1.1 |
| Description |
Cystathionine gamma-lyase |
| Alternative names |
Homoserine deaminase;
Homoserine dehydratase;
Gamma-cystathionase;
Cystine desulfhydrase;
Cysteine desulfhydrase (ambiguous);
Cystathionase;
Cystathioninase. |
| Catalyzed reaction |
L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate. |
| Cofactor |
Pyridoxal-phosphate. |
| Comments |
-!- Also catalyzes elimination reactions of L-homoserine to form H(2)O, NH(3) and 2-oxobutanoate, of L-cystine, producing thiocysteine, pyruvate and NH(3), and of L-cysteine producing pyruvate, NH(3) and H(2)S.
-!- Formerly EC 4.2.1.15. |
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Often, these enzymes also exhibit gamma-synthase activity (EC 2.5.1.48), making their exact classification difficult. Indeed, the gene from H. pylori has recently been assigned a gamma-synthase function.
The enzyme from Lactococcus lactis can carry out both an alpha,gamma-elimination and an alpha,beta-elimination reactions on cystathionine, hence in some database entries this gene is classified as cystathionine beta-lyase (EC 4.1.4.8) |
| Diseases |
Cystathioninuria |
| Prosite |
PROSITE; PDOC00677; |
| PDB |
1N8P; 4IYO; |
| Organisms |
-Eubacteria -Plants -Fungi -Metazoa -Human |
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| Links |
Enzyme (activities) 4.4.1.1
BRENDA (activities) 4.4.1.1
KEGG (pathways) 4.4.1.1
PLPMDB (PLP mutants) 4.4.1.1
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| References |
Articles on 4.4.1.1 |
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| last changed |
2019/06/20 13:02 |
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