Activities | Families | Sequences | Fold types | References | Help
B6db activities: 4.4.1.11

4.4.1.11
Description Methionine gamma-lyase.
Alternative names L-methioninase;
Methionine lyase;
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase;
METase.
Catalyzed reaction L-methionine = methanethiol + NH(3) + 2-oxobutanoate.
Cofactor Pyridoxal-phosphate.
Prosite PROSITE; PDOC00677;
PDB 1GC0; 1E5F;
Organisms -Bacteria -Metazoa
 

Family 

4.4.1.11 (16)
 
Links Enzyme (activities) 4.4.1.11
BRENDA (activities) 4.4.1.11
KEGG (pathways) 4.4.1.11
PLPMDB (PLP mutants) 4.4.1.11
 
References
 Fukamachi, H.; Nakano, Y.; Okano, S.; Shibata, Y.; Abiko, Y.; Yamashita, Y. (2005) High production of methyl mercaptan by L-methionine-alpha-deamino-gamma-mercaptomethane lyase from Treponema denticola Biochem Biophys Res Commun 331 127-31.

 Mamaeva, D.V.; Morozovam, E.A.; Nikulinm, A.D.; Revtovichm, S.V.; Nikonovm, S.V.; Garberm, M.B.; Demidkina, T.V. (2005) Structure of Citrobacter freundiiL-methionine gamma-lyase Acta Crystallograph Sect F Struct Biol Cryst Commun. 61 546-9.

 Manukhov, IV, Mamaeva, DV, Rastorguev, SM, Faleev, NG, Morozova, EA, Demidkina, TV, Zavilgelsky, GB. (2005) A gene encoding L-methionine gamma-lyase is present in Enterobacteriaceae family genomes: identification and characterization of Citrobacter freundii L-methionine gamma-lyase J Bacteriol 187 3889-93.

 Tokoro, M.; Asai, T.; Kobayashi, S.; Takeuchi, T.; Nozaki, T. (2003) Identification and characterization of two isoenzymes of methionine gamma-lyase from Entamoeba histolytica: a key enzyme of sulfur-amino acid degradation in an anaerobic parasitic protist that lacks forward and reverse trans-sulfuration pathways J Biol Chem 278 42717-27.

 Motoshima, H.; Inagaki, K.; Kumasaka, T.; Furuichi, M.; Inoue, H.; Tamura, T.; Esaki, N.; Soda, K.; Tanaka, N.; Yamamoto, M.; Tanaka, H. (2000) Crystal structure of the pyridoxal 5'-phosphate dependent L-methionine gamma-lyase from Pseudomonas putida J Biochem (Tokyo) 128 349-54.

 Yoshimura, M.; Nakano, Y.; Yamashita, Y.; Oho, T.; Saito, T.; Koga, T. (2000) Formation of methyl mercaptan from L-methionine by Porphyromonas gingivalis Infect Immun 68 6912-6.

 McKie, A. E.; Edlind, T.; Walker, J.; Mottram, J. C.; Coombs, G. H. (1998) The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes J Biol Chem 273 5549-56.

 Hori H, Takabayashi K, Orvis L, Carson DA, Nobori T. (1996) Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase Cancer Res 56 2116-22.

Articles on 4.4.1.11
 
last changed 2009/07/13 10:19

B6db activities