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B6db activities:
Description Cysteine-S-conjugate beta-lyase
Alternative names Alkyl cysteine lyase.
Alkylcysteine lyase.
Cystathionine beta-lyase.
Cystine lyase.
L-cysteine-S-conjugate thiol-lyase (deaminating).
S-alkyl-L-cysteine lyase.
S-alkyl-L-cysteine sulfoxide lyase.
S-alkylcysteine lyase.
Catalyzed reaction RS-CH(2)-CH(NH(3)(+))COO(-) = RSH + NH(3) + pyruvate.
Cofactor Pyridoxal-phosphate.
Comments -!- R may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitrobenzene.
Several PLP-dependent enzymes (mainly aminotransferases) show this activity, possibly as a side reaction.

In the public databases, sequences explicitly associated with this function also show kynurenine aminotransferase (EC and glutamine-phenylpyruvate transaminase (EC activities. These sequences have been included in the family.

Organisms -Eubacteria -Plants -Fungi -Metazoa
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Pinto JT, Krasnikov BF, Alcutt S, Jones ME, Dorai T, Villar MT, Artigues A, Li J, Cooper AJ (2014) Kynurenine aminotransferase III and glutamine transaminase L are identical enzymes that have cysteine S-conjugate β-lyase activity and can transaminate L-selenomethionine J Biol Chem 289 30950-61.

 Cooper AJ, Pinto JT. (2006) Cysteine S-conjugate beta-lyases Amino Acids 30 1-15.

 Cooper, A. J.; Bruschi, S. A.; Iriarte, A.; Martinez-Carrion, M. (2002) Mitochondrial aspartate aminotransferase catalyses cysteine S-conjugate beta-lyase reactions Biochem J 368 253-261.

 Kitamura, N.; Shimomura, N.; Iseki, J.; Honma, M.; Chiba, S.; Tahara, S.; Mizutani, J. (1997) Cysteine-S-conjugate beta-lyase activity and pyridoxal phosphate binding site of onion alliin lyase Biosci Biotechnol Biochem 61 1327-30.

 Alberati-Giani, D.; Malherbe, P.; Kohler, C.; Lang, G.; Kiefer, V.; Lahm, H. W.; Cesura, A. M. (1995) Cloning and characterization of a soluble kynurenine aminotransferase from rat brain: identity with kidney cysteine conjugate beta-lyase J Neurochem 64 1448-55.

Articles on
last changed 2019/01/31 11:30

B6db activities