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B6db activities: 4.4.1.13

4.4.1.13
Description Cysteine-S-conjugate beta-lyase.
Catalyzed reaction RS-CH(2)-CH(NH(3)(+))COO(-) = RSH + NH(3) + pyruvate.
Cofactor Pyridoxal-phosphate.
Comments -!- R may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitrobenzene.
Several PLP-dependent enzymes (mainly aminotransferases) show this activity, possibly as a side reaction.

In the public databases, sequences explicitly associated with this function also show kynurenine aminotransferase (EC 2.6.1.7) and glutamine-phenylpyruvate transaminase (EC 2.6.1.64) activities. These sequences have been included in the 2.6.1.7 family.

Organisms -Eubacteria -Plants -Fungi -Metazoa
 
 
Links Enzyme (activities) 4.4.1.13
BRENDA (activities) 4.4.1.13
KEGG (pathways) 4.4.1.13
PLPMDB (PLP mutants) 4.4.1.13
 
References
 Cooper AJ, Pinto JT. (2006) Cysteine S-conjugate beta-lyases Amino Acids 30 1-15.

 Cooper, A. J.; Bruschi, S. A.; Iriarte, A.; Martinez-Carrion, M. (2002) Mitochondrial aspartate aminotransferase catalyses cysteine S-conjugate beta-lyase reactions Biochem J 368 253-261.

 Kitamura, N.; Shimomura, N.; Iseki, J.; Honma, M.; Chiba, S.; Tahara, S.; Mizutani, J. (1997) Cysteine-S-conjugate beta-lyase activity and pyridoxal phosphate binding site of onion alliin lyase Biosci Biotechnol Biochem 61 1327-30.

 Alberati-Giani, D.; Malherbe, P.; Kohler, C.; Lang, G.; Kiefer, V.; Lahm, H. W.; Cesura, A. M. (1995) Cloning and characterization of a soluble kynurenine aminotransferase from rat brain: identity with kidney cysteine conjugate beta-lyase J Neurochem 64 1448-55.

Articles on 4.4.1.13
 
last changed 2010/03/11 16:27

B6db activities