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B6db activities: 4.4.1.25

4.4.1.25
Description L-cysteate sulfo-lyase
Alternative names L-cysteate sulfo-lyase (deaminating);
CuyA.
Catalyzed reaction L-cysteate + H2O = pyruvate + bisulfite + NH3
Cofactor Pyridoxal-phosphate.
Comments A pyridoxal-phosphate protein. D-Cysteine can also act as a substrate, but more slowly. It is converted into pyruvate, sulfide and NH3. This inducible enzyme from the marine bacterium Silicibacter pomeroyi DSS-3 forms part of the cysteate-degradation pathway.
In the original paper (Denger et al. 2006 Biochem J. 394 657-64) the enzyme was called L-cysteate sulfo-lyase. However, in a subsequent paper (Denger et al. 2009 J Bacteriol 191 5648-56) the same enzyme was termed (S)-cysteate sulfo-lyase.
(S)-cysteate should correspond to the D- (not L) form of the amino acid. This would agree with the activity shown by the Silicibater enzyme towards D-cysteine.
Organisms -Eubacteria
 

Family 

4.4.1.25 (7)
 
Links Enzyme (activities) 4.4.1.25
BRENDA (activities) 4.4.1.25
KEGG (pathways) 4.4.1.25
PLPMDB (PLP mutants) 4.4.1.25
 
References Articles on 4.4.1.25
 
last changed 2016/10/06 17:22

B6db activities