B6db activities : 5_1_1

	Activities \| Families \| Sequences \| Fold types \| References \| Help


	5.1.1.15
Description	2-aminohexano-6-lactam racemase.
Alternative names	2-amino-hexano-6-lactam racemase; Alpha-amino-epsilon-caprolactam racemase; Aminocaprolactam racemase; ACL racemase.
Catalyzed reaction	L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam.
Cofactor	Pyridoxal-phosphate.
Comments	-!- Also interconverts 2-aminopentano-5-lactam (alpha-amino-delta-valerolactam) and 2-amino-4-thiahexano-6-lactam (where S replaces CH(2) of C-4). -!- It does not catalyse the racemisation of alpha-amino acids but has some transaminase activity with them.
PDB	3DXV;
Organisms	-Eubacteria
Family	5.1.1.15 (5)

Links	Enzyme (activities) 5.1.1.15 BRENDA (activities) 5.1.1.15 KEGG (pathways) 5.1.1.15 PLPMDB (PLP mutants) 5.1.1.15

References	Okazaki S, Suzuki A, Mizushima T, Kawano T, Komeda H, Asano Y, Yamane T. (2009) The novel structure of a pyridoxal 5'-phosphate-dependent fold-type I racemase, alpha-amino-epsilon-caprolactam racemase from Achromobacter obae Biochemistry 48 941-50. Asano Y, Yamaguchi S. (2005) Dynamic kinetic resolution of amino acid amide catalyzed by D-aminopeptidase and alpha-amino-epsilon-caprolactam racemase J Am Chem Soc 127 7696-7. Asano Y, Yamaguchi S. (2005) Discovery of amino acid amides as new substrates for α-amino--caprolactam racemase from Achromobacter obae Journal of Molecular Catalysis B: Enzymatic 36 22-29. Nakamura, N.; Oshihara, W.; Yanai,A. (1987) alpha-Amino-epsilon-caprolactam racemase for L-lysine production BIOCHEMISTRY OF VITAMIN B6 (Korpela,T. and Christen, P. Eds.) Birkhauser Verlag 449-452. Articles on 5.1.1.15

last changed	2010/02/02 10:19

Family