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B6db activities: 5.1.1.15

5.1.1.15
Description 2-aminohexano-6-lactam racemase
Alternative names 2-amino-hexano-6-lactam racemase;
Alpha-amino-epsilon-caprolactam racemase;
Aminocaprolactam racemase;
ACL racemase.
Catalyzed reaction L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam.
Cofactor Pyridoxal-phosphate.
Comments -!- Also interconverts 2-aminopentano-5-lactam (alpha-amino-delta-valerolactam) and 2-amino-4-thiahexano-6-lactam (where S replaces CH(2) of C-4).
-!- It does not catalyse the racemisation of alpha-amino acids but has some transaminase activity with them.
PDB 3DXV;
Organisms -Eubacteria
 

Family 

5.1.1.15 (10)
 
Links Enzyme (activities) 5.1.1.15
BRENDA (activities) 5.1.1.15
KEGG (pathways) 5.1.1.15
PLPMDB (PLP mutants) 5.1.1.15
 
References
 Matsui D, Fuhshuku KI, Nagamori S, Takata M, Asano Y (2017) Isolation and characterization of racemase from Ensifer sp. 23-3 that acts on α-aminolactams and α-amino acid amides J Ind Microbiol Biotechnol 44 1503-1510.

 Okazaki S, Suzuki A, Mizushima T, Kawano T, Komeda H, Asano Y, Yamane T. (2009) The novel structure of a pyridoxal 5'-phosphate-dependent fold-type I racemase, alpha-amino-epsilon-caprolactam racemase from Achromobacter obae Biochemistry 48 941-50.

 Asano Y, Yamaguchi S. (2005) Dynamic kinetic resolution of amino acid amide catalyzed by D-aminopeptidase and alpha-amino-epsilon-caprolactam racemase J Am Chem Soc 127 7696-7.

 Asano Y, Yamaguchi S. (2005) Discovery of amino acid amides as new substrates for α-amino--caprolactam racemase from Achromobacter obae Journal of Molecular Catalysis B: Enzymatic 36 22-29.

 Nakamura, N.; Oshihara, W.; Yanai,A. (1987) alpha-Amino-epsilon-caprolactam racemase for L-lysine production BIOCHEMISTRY OF VITAMIN B6 (Korpela,T. and Christen, P. Eds.) Birkhauser Verlag 449-452.

Articles on 5.1.1.15
 
last changed 2019/06/20 13:36

B6db activities