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B6db activities: 5.1.1.17

5.1.1.17
Description Isopenicillin N epimerase
Alternative names Penicillin-N 5-amino-5-carboxypentanoyl-epimerase.
Catalyzed reaction Isopenicillin N = penicillin N
Cofactor Pyridoxal-phosphate.
Comments Epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC 1.14.20.1, to produce cephalosporins. Forms part of the penicillin biosynthesis pathway.
While bacterial enzymes are PLP dependent, the formation of penicillin N in the fungus Acremonium chrysogenum requires a two-component protein system that comprises an isopenicillinyl-CoA ligase and an isopenicillinyl-CoA epimerase.
Organisms -Eubacteria
 

Family 

5.1.1.17 (4)
 
Links Enzyme (activities) 5.1.1.17
BRENDA (activities) 5.1.1.17
KEGG (pathways) 5.1.1.17
PLPMDB (PLP mutants) 5.1.1.17
 
References Articles on 5.1.1.17
 
last changed 2010/02/02 10:19

B6db activities