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B6db activities:
Description Isopenicillin N epimerase
Alternative names Penicillin-N 5-amino-5-carboxypentanoyl-epimerase.
Catalyzed reaction Isopenicillin N = penicillin N
Cofactor Pyridoxal-phosphate.
Comments Epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC, to produce cephalosporins. Forms part of the penicillin biosynthesis pathway.
While bacterial enzymes are PLP dependent, the formation of penicillin N in the fungus Acremonium chrysogenum requires a two-component protein system that comprises an isopenicillinyl-CoA ligase and an isopenicillinyl-CoA epimerase.
Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2010/02/02 10:19

B6db activities