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5.1.1.17 |
Description |
Isopenicillin N epimerase |
Alternative names |
Penicillin-N 5-amino-5-carboxypentanoyl-epimerase. |
Catalyzed reaction |
Isopenicillin N = penicillin N |
Cofactor |
Pyridoxal-phosphate. |
Comments |
Epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC 1.14.20.1, to produce cephalosporins.
Forms part of the penicillin biosynthesis pathway. |
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While bacterial enzymes are PLP dependent, the formation of penicillin N in the fungus Acremonium chrysogenum requires a two-component protein system that comprises an isopenicillinyl-CoA ligase and an isopenicillinyl-CoA epimerase. |
Organisms |
-Eubacteria |
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Family |
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Links |
Enzyme (activities) 5.1.1.17
BRENDA (activities) 5.1.1.17
KEGG (pathways) 5.1.1.17
PLPMDB (PLP mutants) 5.1.1.17
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References |
Articles on 5.1.1.17 |
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last changed |
2010/02/02 10:19 |
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