B6db activities : 1_17_1

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	1.17.1.1
Description	CDP-4-dehydro-6-deoxyglucose reductase
Alternative names	CDP-4-keto-6-deoxy-D-glucose-3-dehydrase; CDP-6-deoxy-L-threo-D-glycero-4-hexulose 3-dehydrase; CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system.
Catalyzed reaction	CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD(P)+ + H2O = CDP-4-dehydro-6-deoxy-D-glucose + NAD(P)H + H+
Cofactor	Pyridoxamine-phosphate and iron-sulfur cluster.
Comments	The enzyme consists of two proteins. One forms an enzyme-bound adduct of the CDP-4-dehydro-6-deoxyglucose with pyridoxamine phosphate, in which the 3-hydroxy group has been removed. The second catalyses the reduction of this adduct by NAD(P)H and release of the CDP-4-dehydro-3,6-dideoxy-D-glucose and pyridoxamine phosphate.
	The first protein, termed E1, is CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase, which is a pyridoxamine 5'-phosphate dependent iron-sulfur protein. The second protein, CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase reductase, formally called CDP-6-deoxy-delta(3,4)-glucoseen reductase (E3), is an NADH dependent [2Fe-2S]-containing flavoenzyme.
PDB	3BCX;
Organisms	-Eubacteria
Family	1.17.1.1 (0)

Links	Enzyme (activities) 1.17.1.1 BRENDA (activities) 1.17.1.1 KEGG (pathways) 1.17.1.1 PLPMDB (PLP mutants) 1.17.1.1

References	Articles on 1.17.1.1

last changed	2017/10/10 14:11

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