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B6db activities:
Description CDP-4-dehydro-6-deoxyglucose reductase
Alternative names CDP-4-keto-6-deoxy-D-glucose-3-dehydrase;
CDP-6-deoxy-L-threo-D-glycero-4-hexulose 3-dehydrase;
CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system.
Catalyzed reaction CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD(P)+ + H2O = CDP-4-dehydro-6-deoxy-D-glucose + NAD(P)H + H+
Cofactor Pyridoxamine-phosphate and iron-sulfur cluster.
Comments The enzyme consists of two proteins. One forms an enzyme-bound adduct of the CDP-4-dehydro-6-deoxyglucose with pyridoxamine phosphate, in which the 3-hydroxy group has been removed. The second catalyses the reduction of this adduct by NAD(P)H and release of the CDP-4-dehydro-3,6-dideoxy-D-glucose and pyridoxamine phosphate.
The first protein, termed E1, is CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase, which is a pyridoxamine 5'-phosphate dependent iron-sulfur protein. The second protein, CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase reductase, formally called CDP-6-deoxy-delta(3,4)-glucoseen reductase (E3), is an NADH dependent [2Fe-2S]-containing flavoenzyme.
Organisms -Eubacteria

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Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
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last changed 2017/10/10 14:11

B6db activities