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Description Glycine dehydrogenase (decarboxylating)
Alternative names Glycine decarboxylase;
glycine cleavage system P-protein;
glycine-cleavage complex;
glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating);
protein P1
Catalyzed reaction glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- Lipoamide can also act as acceptor.
-!- A component, with EC, aminomethyltransferase and EC, dihydrolipoyl dehydrogenanse, of the glycine cleavage system, previously known as glycine synthase. The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC, the T protein (EC, the L protein (EC and the lipoyl-bearing H protein.
The P protein from archaea and from certain (gram positive) bacteria is formed by two subunits. See for example: gi|14591729|ref|NP_143817.1| glycine dehydrogenase subunit 1 [Pyrococcus horikoshii] gi|14591728|ref|NP_143816.1| glycine dehydrogenase subunit 2 [Pyrococcus horikoshii]. Even though these subunits are phylogenetically related, only one apparently retains the ability to bind PLP (subunit 2 in the example above). In other eubacteria and in eukarya, a single polypeptide contains domains corresponding to the subunits 1 and 2.
Diseases Nonketotic hyperglycinemia type II
Organisms -All -Eubacteria -Archea -Plants -Fungi -Metazoa -Human
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2017/10/10 14:10

B6db activities