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B6db activities: 1.4.4.2

1.4.4.2
Description Glycine dehydrogenase (decarboxylating)
Alternative names Glycine decarboxylase;
glycine cleavage system P-protein;
P-protein;
glycine-cleavage complex;
glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating);
protein P1
Catalyzed reaction glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- Lipoamide can also act as acceptor.
-!- A component, with EC 2.1.2.10, aminomethyltransferase and EC 1.8.1.4, dihydrolipoyl dehydrogenanse, of the glycine cleavage system, previously known as glycine synthase. The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
The P protein from archaea and from certain (gram positive) bacteria is formed by two subunits. See for example: gi|14591729|ref|NP_143817.1| glycine dehydrogenase subunit 1 [Pyrococcus horikoshii] gi|14591728|ref|NP_143816.1| glycine dehydrogenase subunit 2 [Pyrococcus horikoshii]. Even though these subunits are phylogenetically related, only one apparently retains the ability to bind PLP (subunit 2 in the example above). In other eubacteria and in eukarya, a single polypeptide contains domains corresponding to the subunits 1 and 2.
Diseases Nonketotic hyperglycinemia type II
PDB 1WYU; 4LDH; 4LHC;
Organisms -All -Eubacteria -Archea -Plants -Fungi -Metazoa -Human
 
 
Links Enzyme (activities) 1.4.4.2
BRENDA (activities) 1.4.4.2
KEGG (pathways) 1.4.4.2
PLPMDB (PLP mutants) 1.4.4.2
 
References Articles on 1.4.4.2
 
last changed 2017/10/10 14:10

B6db activities