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B6db activities:
Description Glycine dehydrogenase (decarboxylating)
Alternative names Glycine decarboxylase;
glycine cleavage system P-protein;
glycine-cleavage complex;
glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating);
protein P1
Catalyzed reaction glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- Lipoamide can also act as acceptor.
-!- A component, with EC, aminomethyltransferase and EC, dihydrolipoyl dehydrogenanse, of the glycine cleavage system, previously known as glycine synthase. The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC, the T protein (EC, the L protein (EC and the lipoyl-bearing H protein.
The P protein from archaea and from certain (gram positive) bacteria is formed by two subunits. See for example: gi|14591729|ref|NP_143817.1| glycine dehydrogenase subunit 1 [Pyrococcus horikoshii] gi|14591728|ref|NP_143816.1| glycine dehydrogenase subunit 2 [Pyrococcus horikoshii]. Even though these subunits are phylogenetically related, only one apparently retains the ability to bind PLP (subunit 2 in the example above). In other eubacteria and in eukarya, a single polypeptide contains domains corresponding to the subunits 1 and 2.
Diseases Nonketotic hyperglycinemia type II
Organisms -All -Eubacteria -Archea -Plants -Fungi -Metazoa -Human

Family (31)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Hasse D.; Mikkat S.; Thrun H.A.; Hagemann, M.; Bauwe, H. (2007) Properties of recombinant glycine decarboxylase P- and H-protein subunits from the cyanobacterium Synechocystis sp. strain PCC 6803. FEBS Lett 581 1297-301.

 Nakai T, Nakagawa N, Maoka N, Masui R, Kuramitsu S, Kamiya N. (2005) Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia EMBO J 24 1523-1536.

 Douce, R.; Bourguignon, J.; Neuburger, M.; Rebeille, F. (2001) The glycine decarboxylase system: a fascinating complex Trends Plant Sci 6 167-76.

 Sinclair, D.A.; Hong, S.P.; Dawes, I.W. (1996) Specific induction by glycine of the gene for the P-subunit of glycine decarboxylase from Saccharomyces cerevisiae Mol Microbiol 19 611-23.

 Turner, S.R.; Ireland, R.; Rawsthorne, S. (1992) Cloning and characterization of the P subunit of glycine decarboxylase from pea (Pisum sativum) J Biol Chem 267 5355-60.

 Fujiwara, K.; Okamura-Ikeda, K.; Motokawa, Y. (1987) Amino acid sequence of the phosphopyridoxyl peptide from P-protein of the chicken liver glycine cleavage system Biochem Biophys Res Commun 149 621-7.

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last changed 2017/10/10 14:10

B6db activities