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B6db activities: 2.3.1.47

2.3.1.47
Description 8-amino-7-oxononanoate synthase
Alternative names AONS;
8-amino-7-ketopelargonate synthase;
7-keto-8-amino-pelargonic acid synthetase.;
7-KAP synthetase.
KAPA synthase;
alpha-Oxoamine Synthase (ambiguous;
BioF (gene name)
Catalyzed reaction 6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7-oxononanoate + CoA + CO(2).
Cofactor Pyridoxal-phosphate.
Comments The known enzymes with this activity show a strict phylogenetic relationship to glycine acetyltransferases (EC 2.3.1.29).
Indeed, some of these enzymes possess a broad substrate specificity, performing also the glycine acetyltransferase reaction.
Prosite PROSITE; PDOC00518;
PDB 1DJE; 1DJ9; 1BS0;
Organisms -Eubacteria -Archea -Plants -Fungi
 

Family 

2.3.1.47 (37)
 
Links Enzyme (activities) 2.3.1.47
BRENDA (activities) 2.3.1.47
KEGG (pathways) 2.3.1.47
PLPMDB (PLP mutants) 2.3.1.47
 
References
 Ren X, Wang X, Shi H, Zhang X, Chen Z, Malhi KK, Ding C, Yu S (2018) Riemerella anatipestifer AS87_RS09170 gene is responsible for biotin synthesis, bacterial morphology and virulence Sci Rep 8 14645.

 Kubota T, Izumi Y. (2012) Detection and characterization of a thermophilic biotin biosynthetic enzyme, 7-keto-8-aminopelargonic acid synthase, from various thermophiles. Biosci Biotechnol Biochem 76 685-90.

 Kubota T, Shimono J, Kanameda C, Izumi Y. (2007) The first Thermophilic alpha-oxoamine synthase family enzyme that has activities of 2-amino-3-ketobutyrate CoA ligase and 7-keto-8-aminopelargonic acid synthase: Cloning and overexpression of the gene from an extreme thermophile, Thermus thermophilus, and characterization of its gene product Biosci Biotechnol Biochem 23 3033-3040.

 Bhor VM, Dev S, Vasanthakumar GR, Kumar P, Sinha S, Surolia A. (2006) Broad substrate stereospecificity of the Mycobacterium tuberculosis 7-keto-8-aminopelargonic acid synthase: Spectroscopic and kinetic studies J Biol Chem 281 25076-88.

 Pinon V, Ravanel S, Douce R, Alban C. (2005) Biotin synthesis in plants. The first committed step of the pathway is catalyzed by a cytosolic 7-keto-8-aminopelargonic acid synthase Plant Physiol 139 1666-76.

 Alexeev, D.; Alexeeva, M.; Baxter, R. L.; Campopiano, D. J.; Webster, S. P.; Sawyer, L. (1998) The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme J Mol Biol 284 401-19.

 Ploux, O.; Marquet, A. (1992) The 8-amino-7-oxopelargonate synthase from Bacillus sphaericus. Purification and preliminary characterization of the cloned enzyme overproduced in Escherichia coli Biochem J 283 327-31.

Articles on 2.3.1.47
 
last changed 2019/06/20 13:26

B6db activities