|
|
2.3.1.47 |
Description |
8-amino-7-oxononanoate synthase |
Alternative names |
AONS; 8-amino-7-ketopelargonate synthase; 7-keto-8-amino-pelargonic acid synthetase.; 7-KAP synthetase.
KAPA synthase;
alpha-Oxoamine Synthase (ambiguous;
BioF (gene name)
|
Catalyzed reaction |
6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7-oxononanoate + CoA + CO(2). |
Cofactor |
Pyridoxal-phosphate. |
Comments |
The known enzymes with this activity show a strict phylogenetic relationship to glycine acetyltransferases (EC 2.3.1.29).
Indeed, some of these enzymes possess a broad substrate specificity, performing also the glycine acetyltransferase reaction. |
Prosite |
PROSITE; PDOC00518; |
PDB |
1DJE; 1DJ9; 1BS0; |
Organisms |
-Eubacteria -Archea -Plants -Fungi |
| |
Family |
|
| |
Links |
Enzyme (activities) 2.3.1.47
BRENDA (activities) 2.3.1.47
KEGG (pathways) 2.3.1.47
PLPMDB (PLP mutants) 2.3.1.47
|
| |
References |
Ren X, Wang X, Shi H, Zhang X, Chen Z, Malhi KK, Ding C, Yu S (2018) Riemerella anatipestifer AS87_RS09170 gene is responsible for biotin synthesis, bacterial morphology and virulence Sci Rep 8 14645. Kubota T, Izumi Y.
(2012) Detection and characterization of a thermophilic biotin biosynthetic enzyme, 7-keto-8-aminopelargonic acid synthase, from various thermophiles. Biosci Biotechnol Biochem 76 685-90. Kubota T, Shimono J, Kanameda C, Izumi Y.
(2007) The first Thermophilic alpha-oxoamine synthase family enzyme that has activities of 2-amino-3-ketobutyrate CoA ligase and 7-keto-8-aminopelargonic acid synthase: Cloning and overexpression of the gene from an extreme thermophile, Thermus thermophilus, and characterization of its gene product Biosci Biotechnol Biochem 23 3033-3040. Bhor VM, Dev S, Vasanthakumar GR, Kumar P, Sinha S, Surolia A. (2006) Broad substrate stereospecificity of the Mycobacterium tuberculosis 7-keto-8-aminopelargonic acid synthase: Spectroscopic and kinetic studies J Biol Chem 281 25076-88. Pinon V, Ravanel S, Douce R, Alban C. (2005) Biotin synthesis in plants. The first committed step of the pathway is catalyzed by a cytosolic 7-keto-8-aminopelargonic acid synthase Plant Physiol 139 1666-76. Alexeev, D.; Alexeeva, M.; Baxter, R. L.; Campopiano, D. J.; Webster, S. P.; Sawyer, L. (1998) The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme J Mol Biol 284 401-19. Ploux, O.; Marquet, A. (1992) The 8-amino-7-oxopelargonate synthase from Bacillus sphaericus. Purification and preliminary characterization of the cloned enzyme overproduced in Escherichia coli Biochem J 283 327-31. Articles on 2.3.1.47 |
| |
last changed |
2019/06/20 13:26 |
|