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B6db activities: 2.3.1.50

2.3.1.50
Description Serine C-palmitoyltransferase
Alternative names serine palmitoyltransferase;
SPT;
3-oxosphinganine synthetase;
acyl-CoA:serine C-2 acyltransferase (decarboxylating)
Catalyzed reaction Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments Serine C-palmitoyltransferase belongs to a subset PLP-depentent enzymes collectively known as 2-oxoamine synthases. Oxoamine synthases are involved in several very important primary biosynthetic pathways: SPT in sphingolipid biosynthesis, 5-aminolevulinate synthase (EC 2.3.1.37) in heme biosynthesis, and 8-amino-7-oxononanoate synthase (EC 2.3.1.47) in biotin biosynthesis.
In mammals, serine palmitoyltransferase comprises two different but homologous subunits, LCB1 (most likely a membrane-bound protein) and LCB2. In this database, the two subunits have been included in subfamily a and b, respectively. (Note: LCB1 IS NOT PLP-DEPENDENT)
In humans, these two subunits may combine with a third one (similar but not identical to LCB2) forming in a high-molecular mass complex that appears to reside on the endoplasmic membrane.
Diseases hereditary sensory neuropathy type I
Prosite PROSITE; PDOC00518;
PDB 2JG2; 4BMK;
Organisms -Eubacteria -Plants -Fungi -Metazoa -Human
 
 
Links Enzyme (activities) 2.3.1.50
BRENDA (activities) 2.3.1.50
KEGG (pathways) 2.3.1.50
PLPMDB (PLP mutants) 2.3.1.50
 
References Articles on 2.3.1.50
 
last changed 2017/10/10 14:13

B6db activities