2.4.1.1
Description	Phosphorylase
Alternative names	Muscle phosphorylase A and B; Amylophosphorylase; Polyphosphorylase.
Catalyzed reaction	{(1,4)-alpha-D-glucosyl}(N) + phosphate = {(1,4)-alpha-D-glucosyl}(N-1) + alpha-D-glucose 1-phosphate.
Cofactor	Pyridoxal-phosphate.
Comments	-!- The recommended name should be qualified in each instance by adding the name of the natural substance, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase.
	Phosphorylases are unusual PLP-dependent enzymes, in that the reactive part of the cofactor is not the aromatic aldehyde moiety, but rather the phosphate group, which functions as a general acid/base catalyst.
Diseases	Glycogen storage diseases V and VI.
Prosite	PROSITE; PDOC00095;
PDB	1GPB; 7GPB; 1ABB; 1AHP; 1L5W; 1LWN;
Organisms	-Eubacteria -Archea -Plants -Fungi -Metazoa -Human
Links	Enzyme (activities) 2.4.1.1 BRENDA (activities) 2.4.1.1 KEGG (pathways) 2.4.1.1 PLPMDB (PLP mutants) 2.4.1.1
References	Articles on 2.4.1.1
last changed	2018/05/24 13:30