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B6db activities:
Description N-(2-amino-2-carboxyethyl)-L-glutamate synthase
Alternative names SbnA;
ACEGA synthase;
L-2,3-diaminopropionate synthase, protein A
Catalyzed reaction O-phospho-L-serine + L-glutamate = N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate
Cofactor Pyridoxal phosphate.
Comments the enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B.
SbnA uses O-phospho-L-serine and L-glutamate to produce the unusual metabolite N-(2-amino-2-carboxyethyl)-L-glutamate (ACEGA), which in turn is oxidatively hydrolyzed by a second protein (SbnB) to yield α-ketoglutarate and L-2,3-diaminopropionic acid. In Staphylococcus aureus, the SbnA reaction is the first in the synthesis of the siderophore staphyloferrin B.
PDB 5D84; 5D85;
Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Kobylarz MJ, Grigg JC, Liu Y, Lee MS, Heinrichs DE, Murphy ME (2016) Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis Biochemistry 55 927-39.

 Kobylarz MJ, Grigg JC, Takayama SJ, Rai DK, Heinrichs DE, Murphy M.E. (2014) Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor Chem Biol. 21 379-88.

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last changed 2018/03/19 13:22

B6db activities