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B6db activities:
Description Cystathionine gamma-synthase
Alternative names O-succinylhomoserine (thiol)-lyase;
Homoserine transsuccinylase.;
Cystathionine synthase;
Catalyzed reaction O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.
Cofactor Pyridoxal-phosphate.
Comments -!- Can also use hydrogen sulfide and methanethiol as substrates producing homocysteine and methionine respectively.
-!- In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.

The plant enzyme can also use O-phosphohomoserine as a substrate.

Formerly EC

Subfamily includes enzymes from gram-negative bacteria; subfamily b encompasses enzymes from plants (plastidial proteins) and cyanobacteria.
Prosite PROSITE; PDOC00677;
PDB 1I48; 1I43; 1I41; 1CS1; 1QGN;
Organisms -Eubacteria -Archea -Plants -Fungi
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2010/01/27 18:06

B6db activities