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2.5.1.48 |
| Description |
Cystathionine gamma-synthase |
| Alternative names |
O-succinylhomoserine (thiol)-lyase;
Homoserine transsuccinylase.;
Cystathionine synthase;
MetB. |
| Catalyzed reaction |
O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate. |
| Cofactor |
Pyridoxal-phosphate. |
| Comments |
-!- Can also use hydrogen sulfide and methanethiol as substrates producing homocysteine and methionine respectively.
-!- In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
The plant enzyme can also use O-phosphohomoserine as a substrate.
Formerly EC 4.2.99.9. |
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Subfamily 2.5.1.48a includes enzymes from gram-negative bacteria; subfamily b encompasses enzymes from plants (plastidial proteins) and cyanobacteria. |
| Prosite |
PROSITE; PDOC00677; |
| PDB |
1I48; 1I43; 1I41; 1CS1; 1QGN; |
| Organisms |
-Eubacteria -Archea -Plants -Fungi |
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| Links |
Enzyme (activities) 2.5.1.48
BRENDA (activities) 2.5.1.48
KEGG (pathways) 2.5.1.48
PLPMDB (PLP mutants) 2.5.1.48
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| References |
Articles on 2.5.1.48 |
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| last changed |
2010/01/27 18:06 |
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