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B6db activities: 2.6.1.1

2.6.1.1
Description Aspartate aminotransferase
Alternative names Transaminase A;
Glutamic--oxaloacetic transaminase;
Glutamic--aspartic transaminase;
AspAT;
GOT.
Catalyzed reaction L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor Pyridoxal-phosphate.
Comments -!- Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. This activity can be formed from EC 2.6.1.57 by controlled proteolysis.
Subfamily a includes eukariotic enzymes (both cytosolic and organellar).

Subfamily b encompasses proteins from gram-positive bacteria and from archaea.

Subfamily c is a compact subgroup including the E. coli AAT and other enzymes from proteobacteria.

Subfamily d represents a very distinct subgroup of bacterial enzymes based on the functionally validated sequence from Corynebacterium glutamicum.

Subfamily e is yet another very distinct group, including enzymes from thermophilic Archaea and from Eubacteria.

Subfamily f (distantly related to subfamily b) is based on a very divergent sequence from Bacillus.

Prosite PROSITE; PDOC00098;
PDB 1AAT; 1AAW; 1ASL; 1ARG; 1ARS; 1CQ6; 7AAT; 1J32; 1YAA; 3MEB; 5IWQ; 5C6U; 3HLM; 2X5F;
Organisms -Eubacteria -Archea -Plants -Fungi -Metazoa -Human
 
 
Links Enzyme (activities) 2.6.1.1
BRENDA (activities) 2.6.1.1
KEGG (pathways) 2.6.1.1
PLPMDB (PLP mutants) 2.6.1.1
 
References Articles on 2.6.1.1
 
last changed 2020/03/01 19:52

B6db activities