|
|
| |
2.6.1.103 |
| Description |
(S)-3,5-dihydroxyphenylglycine transaminase |
| Alternative names |
(S)-3,5-dihydroxyphenylglycine transaminase.
L-p-hydroxyphenylglycine transaminase.
(S)-4-hydroxyphenylglycine amino transferase.
HpgT (gene name) |
| Catalyzed reaction |
(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate.
(S)-4-hydroxyphenylglycine + 4-hydroxyphenylpyruvate = 4-hydroxyphenyl-2-oxoacetate + L-tyrosine
|
| Cofactor |
Pyridoxal-phosphate. |
| Comments |
The enzyme from the bacterium Amycolatopsis orientalis catalyses the first reaction in the reverse direction as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin. |
| |
The enzyme from Amycolatopsis orientalis also transaminates L-4-hydroxyphenylglycine (second of the reactions above) and is involved in the synthesis of chloroeremomycin. A similar, characterized enzyme from Streptomyces lavendulae also transaminates L-4-hydroxyphenylglycine and acts in the pathway for the production of complestatin. These enzymes do not use D-p-hydroxyphenylglycine as a substrate and thus are totally distinct from EC 2.6.1.72. |
| Organisms |
-Eubacteria |
| | |
|---|
| | |
|---|
| Links |
Enzyme (activities) 2.6.1.103
BRENDA (activities) 2.6.1.103
KEGG (pathways) 2.6.1.103
PLPMDB (PLP mutants) 2.6.1.103
|
| | |
|---|
| References |
Articles on 2.6.1.103 |
| | |
|---|
| last changed |
2019/05/17 10:02 |
|
Browse:
Analyse:
Find: