Activities | Families | Sequences | Fold types | References | Help
B6db activities:
Description (S)-3,5-dihydroxyphenylglycine transaminase
Alternative names (S)-3,5-dihydroxyphenylglycine transaminase.
L-p-hydroxyphenylglycine transaminase.
(S)-4-hydroxyphenylglycine amino transferase.
HpgT (gene name)
Catalyzed reaction (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate.

(S)-4-hydroxyphenylglycine + 4-hydroxyphenylpyruvate = 4-hydroxyphenyl-2-oxoacetate + L-tyrosine

Cofactor Pyridoxal-phosphate.
Comments The enzyme from the bacterium Amycolatopsis orientalis catalyses the first reaction in the reverse direction as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin.
The enzyme from Amycolatopsis orientalis also transaminates L-4-hydroxyphenylglycine (second of the reactions above) and is involved in the synthesis of chloroeremomycin. A similar, characterized enzyme from Streptomyces lavendulae also transaminates L-4-hydroxyphenylglycine and acts in the pathway for the production of complestatin. These enzymes do not use D-p-hydroxyphenylglycine as a substrate and thus are totally distinct from EC
Organisms -Eubacteria
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2019/05/17 10:02

B6db activities