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B6db activities:
Description 3-dehydro-glucose-6-phosphate--glutamate transaminase
Alternative names α-D-kanosamine 6-phosphate aminotransferase;
oxo-glucose-6-phosphate:glutamate aminotransferase;
NtdA (gene name);
KabA (gene name);
Catalyzed reaction kanosamine 6-phosphate + 2-oxoglutarate = 3-dehydro-D-glucose 6-phosphate + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments The enzyme, found in the bacterium Bacillus subtilis, is involved in a kanosamine biosynthesis pathway.
NtdA from Bacillus subtilis is a sugar aminotransferase that catalyzes the pyridoxal phosphate-dependent equatorial transamination. The structure of NtdA alone reveals the internal aldimine form of NtdA with the cofactor pyridoxal phosphate covalently attached to Lys-247.
Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Prasertanan T, Palmer DRJ (2019) The kanosamine biosynthetic pathway in Bacillus cereus UW85: Functional and kinetic characterization of KabA, KabB, and KabC Arch Biochem Biophys 676 108139.

 van Straaten KE, Ko JB, Jagdhane R, Anjum S, Palmer DR, Sanders DA (2013) The structure of NtdA, a sugar aminotransferase involved in the kanosamine biosynthetic pathway in Bacillus subtilis, reveals a new subclass of aminotransferases J Biol Chem. 288 34121-30.

 Vetter ND, Langill DM, Anjum S, Boisvert-Martel J, Jagdhane RC, Omene E, Zheng H, van Straaten KE, Asiamah I, Krol ES, Sanders DA, Palmer DR. (2013) A previously unrecognized kanosamine biosynthesis pathway in Bacillus subtilis J Am Chem Soc 135 5970-3.

Articles on
last changed 2019/10/21 09:55

B6db activities