B6db activities : 2_6_1

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	2.6.1.11
Description	Acetylornithine aminotransferase.
Alternative names	acetylornithine 5-aminotransferase N-acetylornithine-delta-transaminase
Catalyzed reaction	N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
Cofactor	Pyridoxal-phosphate.
	This E. coli enzyme exhibits also succinyldiaminopimelate aminotransferase activity (2.6.1.17), and shows similar specificity constants for N-acetylornithine and N-succinyldiaminopimelate.
Prosite	PROSITE; PDOC00519;
Organisms	-Bacteria -Archea -Plants -Fungi
Family	2.6.1.11 (21)

Links	Enzyme (activities) 2.6.1.11 BRENDA (activities) 2.6.1.11 KEGG (pathways) 2.6.1.11 PLPMDB (PLP mutants) 2.6.1.11

References	Rajaram V, Prasad K, Ratna Prasuna P, Ramachandra N, Bharath SR, Savithri HS, Murthy MR. (2006) Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of the biosynthetic N-acetylornithine aminotransferases from Salmonella typhimurium and Escherichia coli Acta Crystallogr Sect F Struct Biol Cryst Commun 62 980-3. Ledwidge, R.; Blanchard, J.S. (1999) The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis. Biochemistry 38 3019-24.. Heimberg, H.; Boyen, A.; Crabeel, M.; Glansdorff, N. (1990) Escherichia coli and Saccharomyces cerevisiae acetylornithine aminotransferase: evolutionary relationship with ornithine aminotransferase Gene 90 69-78.. Articles on 2.6.1.11

last changed	2007/09/20 18:44

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