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B6db activities:
Description dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase
Alternative names dTDP-4-dehydro-2,3,6-trideoxy-D-glucose--glutamate aminotransferase;
dTDP-4-amino-2,3,4,6-tetradeoxy-β-D-threo-hexopyranose-oxoglutarate aminotransferase;
spnR (gene name)
Catalyzed reaction dTDP-4-dehydro-2,3,6-trideoxy-D-glucose + L-glutamate = dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose + 2-oxoglutarate
Cofactor Pyridoxal phosphate.
Comments The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine.
Forosamine is a highly deoxygenated sugar found in several natural products, such as the insecticide spinosyns.

The enzyme from Saccharopolyspora spinosa also catalyzes the transamination of dTDP-4-keto-2,6-dideoxy-d-glucose.

Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2017/09/07 12:03

B6db activities