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B6db activities:
Description Putrescine--pyruvate transaminase
Alternative names Putrescine--pyruvate transaminase;
SpuC (gene name)
Catalyzed reaction putrescine + pyruvate = 4-aminobutanal + L-alanine.
Cofactor Pyridoxal phosphate.
Comments The enzyme, studied in the bacterium Pseudomonas aeruginosa, participates in a putrescine degradation pathway.
Distinct from because the preferred ketoacid substrate is pyruvate rather than 2-oxoglutarate.

As with, the 4-aminobutanal undergoes spontaneous cyclization, forming 1-pyrroline.

Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Galman JL, Gahloth D, Parmeggiani F, Slabu I, Leys D, Turner NJ (2018) Characterization of a Putrescine Transaminase From Pseudomonas putida and its Application to the Synthesis of Benzylamine Derivatives Front Bioeng Biotechnol 6 205.

 Galman,J.L., Slabu,I., Weise,N.J., Iglesias,C., Parmeggiani,F., Lloyd,R.C. and Turner,N.J. (2017) Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases Green Chem 19 361-366.

 Wilding M, Walsh EF, Dorrian SJ, Scott C (2015) Identification of novel transaminases from a 12-aminododecanoic acid-metabolizing Pseudomonas strain Microb Biotechnol 8 665-72.

 Lu CD, Itoh Y, Nakada Y, Jiang Y. (2002) Functional analysis and regulation of the divergent spuABCDEFGH-spuI operons for polyamine uptake and utilization in Pseudomonas aeruginosa PAO1 J Bacteriol 184 3765-73.

Articles on
last changed 2019/01/14 13:32

B6db activities