B6db activities : 2_6_1

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	2.6.1.13
Description	Ornithine--oxo-acid aminotransferase.
Alternative names	Ornithine aminotransferase. Ornithine ketoacid aminotransferase. Ornithine delta-transaminase. L-ornithine 5-aminotransferase.
Catalyzed reaction	L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
Cofactor	Pyridoxal-phosphate.
	The enzyme controls the L-ornithine level in tissues by catalysing the transfer of the delta-amino group of ornithine to 2-oxoglutarate. Fungal enzymes also employ L-lysine as a substrate, yielding L-aminoadipate semialdehyde, a metabolic intermediate that can be used in the biosynthesis of antibiotics.
Diseases	Ornithinemia with gyrate atrophy of choroid and retina
Prosite	PROSITE; PDOC00519;
PDB	1GBN; 2OAT; 1Z7D;
Organisms	-Bacteria -Plants -Fungi -Metazoa -Human
Family	2.6.1.13 (26)

Links	Enzyme (activities) 2.6.1.13 BRENDA (activities) 2.6.1.13 KEGG (pathways) 2.6.1.13 PLPMDB (PLP mutants) 2.6.1.13

References	Funck D, Stadelhofer B, Koch W. (2008) Ornithine-[delta]-aminotransferase is essential for Arginine Catabolism but not for Proline Biosynthesis BMC Plant Biol 8 40. Valmaseda, E.M.; Campoy, S.; Naranjo, L.; Casqueiro, J.; Martin, J.F. (2005) Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an omega-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the omega-aminotransferase Mol Genet Genomics 274 272-82. Gafan, C.; Wilson, J.; Berger, L.C.; Berger, B.J. (2001) Characterization of the ornithine aminotransferase from Plasmodium falciparum. Mol Biochem Parasitol 118 1-10. Storici, P.; Capitani, G.; Muller, R.; Schirmer, T.; Jansonius, J. N. (1999) Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine J Mol Biol 285 297-309.. Jhee, K. H.; Yoshimura, T.; Esaki, N.; Yonaha, K.; Soda, K. (1995) Thermostable ornithine aminotransferase from Bacillus sp. YM-2: purification and characterization J Biochem (Tokyo) 118 101-8.. Delauney, A.J.; Hu, C.A.; Kishor, P.B.; Verma, D.P. (1993) Cloning of ornithine delta-aminotransferase cDNA from Vigna aconitifolia by trans-complementation in Escherichia coli and regulation of proline biosynthesis J Biol Chem 268 18673-8. . Simmaco, M.; John, R. A.; Barra, D.; Bossa, F. (1986) The primary structure of ornithine aminotransferase. Identification of active-site sequence and site of post-translational proteolysis FEBS Lett 199 39-42.. Articles on 2.6.1.13

last changed	2008/04/25 17:30

Family