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B6db activities:
Description Succinyldiaminopimelate aminotransferase
Alternative names Succinyldiaminopimelate transaminase;
N-succinyl-L,L-diaminopimelate aminotransferase;
N-succinyl-L,L-DAP aminotransferase;
DapC (gene name);
TabD (gene name);
Catalyzed reaction N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl- L-2-amino-6-oxoheptanedioate + L-glutamate.
Cofactor Pyridoxal-phosphate.
Comments In E. coli, this activity is carried out also by the enzyme that catalyzes the acetylornitine transaminase reaction (
The gene coding for succinyldiaminopimelate aminotransferase in bacteria is termed DapC. However in the literature confusion still exists regarding the gene acronym-enzyme relationships of the dapC and dapD genes, and in several database annotations dapD genes are still incorrectly reported to encode the N-succinyl-L,L-diaminopimelate aminotransferase.

An enzyme from M. tuberculosis, whose structure has been solved (PDB 2O0R) and which is assumed to possess N-succinyl-L,L-diaminopimelate aminotransferase activity, does not show a high similarity to the only functionally-validated DapC gene (from Bordetella) but rather to enzymes with kynurenine aminotransferase activity (EC

Prosite PROSITE; PDOC00094;
Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2018/12/20 10:56

B6db activities