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B6db activities: 2.6.1.33

2.6.1.33
Description dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase
Alternative names Thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase;
Thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase;
TDP-4-keto-6-deoxy-D-glucose transaminase;
dTDP-4-keto-6-deoxy-D-glucose aminotransferase;
Thymidine diphospho-4-amino-4,6-dideoxyglucose transaminase;
CalS13 (gene name)
D-viosamine synthase;
VioA (gene name);
DesI (gene name);
GerB (gene name);
Catalyzed reaction dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate.
Cofactor Pyridoxal-phosphate.
The enzyme from Micromonospora echinospora, CalS13 (upon which subfamily a is based), is involved in calicheamicin biosynthesis, where it catalyzes the reaction in the direction opposite to the one shown above.

The enterobacterial enzyme VioA (subfamily b) is responsible for the synthesis of D-Viosamine (4-amino-4,6-dideoxy-D-glucose), whose derivatives, such as 4-(N-acetylglycyl)amino-4,6-dideoxy-D-glucose, are component of O-antigen variants. In Streptomyces, the same reaction is exploited in metabolic pathways leading to the production of macrolides.

PDB 4ZAS; 2PO3; 3JU7;
Organisms -Eubacteria
 
 
Links Enzyme (activities) 2.6.1.33
BRENDA (activities) 2.6.1.33
KEGG (pathways) 2.6.1.33
PLPMDB (PLP mutants) 2.6.1.33
 
References Articles on 2.6.1.33
 
last changed 2019/06/24 12:38

B6db activities