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2.6.1.33 |
Description |
dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase |
Alternative names |
Thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase; Thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase; TDP-4-keto-6-deoxy-D-glucose transaminase; dTDP-4-keto-6-deoxy-D-glucose aminotransferase; Thymidine diphospho-4-amino-4,6-dideoxyglucose transaminase; CalS13 (gene name)
D-viosamine synthase;
VioA (gene name);
DesI (gene name);
GerB (gene name);
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Catalyzed reaction |
dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate. |
Cofactor |
Pyridoxal-phosphate. |
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The enzyme from Micromonospora echinospora, CalS13 (upon which subfamily a is based), is involved in calicheamicin biosynthesis, where it catalyzes the reaction in the direction opposite to the one shown above.
The enterobacterial enzyme VioA (subfamily b) is responsible for the synthesis of D-Viosamine (4-amino-4,6-dideoxy-D-glucose), whose derivatives, such as 4-(N-acetylglycyl)amino-4,6-dideoxy-D-glucose, are component of O-antigen variants.
In Streptomyces, the same reaction is exploited in metabolic pathways leading to the production of macrolides. |
PDB |
4ZAS; 2PO3; 3JU7; |
Organisms |
-Eubacteria |
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Links |
Enzyme (activities) 2.6.1.33
BRENDA (activities) 2.6.1.33
KEGG (pathways) 2.6.1.33
PLPMDB (PLP mutants) 2.6.1.33
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References |
Articles on 2.6.1.33 |
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last changed |
2019/06/24 12:38 |
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