|
|
| |
2.6.1.33 |
| Description |
dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase |
| Alternative names |
Thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase;
Thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase;
TDP-4-keto-6-deoxy-D-glucose transaminase;
dTDP-4-keto-6-deoxy-D-glucose aminotransferase;
Thymidine diphospho-4-amino-4,6-dideoxyglucose transaminase;
CalS13 (gene name)
D-viosamine synthase;
VioA (gene name);
DesI (gene name);
GerB (gene name);
|
| Catalyzed reaction |
dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate. |
| Cofactor |
Pyridoxal-phosphate. |
| |
The enzyme from Micromonospora echinospora, CalS13 (upon which subfamily a is based), is involved in calicheamicin biosynthesis, where it catalyzes the reaction in the direction opposite to the one shown above.
The enterobacterial enzyme VioA (subfamily b) is responsible for the synthesis of D-Viosamine (4-amino-4,6-dideoxy-D-glucose), whose derivatives, such as 4-(N-acetylglycyl)amino-4,6-dideoxy-D-glucose, are component of O-antigen variants.
In Streptomyces, the same reaction is exploited in metabolic pathways leading to the production of macrolides. |
| PDB |
4ZAS; 2PO3; 3JU7; |
| Organisms |
-Eubacteria |
| | |
|---|
| | |
|---|
| Links |
Enzyme (activities) 2.6.1.33
BRENDA (activities) 2.6.1.33
KEGG (pathways) 2.6.1.33
PLPMDB (PLP mutants) 2.6.1.33
|
| | |
|---|
| References |
Articles on 2.6.1.33 |
| | |
|---|
| last changed |
2019/06/24 12:38 |
|
Browse:
Analyse:
Find: