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B6db activities:
Description UDP-N-acetylbacillosamine transaminase
Alternative names UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase.
UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase.
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase.
PglE (gene name)
EpsN (gene name)
Catalyzed reaction UDP-N-acetylbacillosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments The enzyme is involved in biosynthesis of UDP- N,N'-diacetylbacillosamine, an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species and O-linked glycosylation of certain L-serine residues in Neisseria species.
Formerly EC
In C. jejuni PglE is involved in the general glycosylation pathway (Pgl) responsible for the N-linked modification of proteins with a heptasaccharide containing 2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose, a derivative of bacillosamine.
Specifically, the product of the PglE aminotransferase is UDP-4-amino-4,6-dideoxy-alpha-D-GlcNAc (UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose) - a precursor used in the production of the Pgl glycan component
PDB 1O61; 4ZTC;
Organisms -Eubacteria


Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2018/12/21 13:21

B6db activities