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B6db activities:
Description (2-aminoethyl)phosphonate--pyruvate aminotransferase
Alternative names (2-aminoethyl)phosphonate aminotransferase;
Ciliatine transaminase.
Catalyzed reaction (2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine;
PhnW (gene name);
Cofactor Pyridoxal-phosphate.
2-Aminoethylphosphonate (ciliatine) is the precursor of an array of phosphonate compounds (e.g., phosphonopolysaccharides), that are employed by some organisms for specialized functions such as chemical warfare, cell-cell communication and host recognition.
PDB 1M32;
Organisms -Eubacteria

Family (17)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Rice K, Batul K, Whiteside J, Kelso J, Papinski M, Schmidt E, Pratasouskaya A, Wang D, Sullivan R, Bartlett C, Weadge JT, Van der Kamp MW, Moreno-Hagelsieb G, Suits MD, Horsman GP (2019) The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis Nat Commun 10 3698.

 Chen, C.C., Zhang, H., Kim, A.D., Howard A., Sheldrick, G.M., Mariano-Dunaway, D., Herzberg O. (2002) Degradation pathway of the phosphonate ciliatine: crystal structure of 2-aminoethylphosphonate transaminase Biochemistry 41 13162-69.

 Kim, A.D.; Baker, A.S.; Dunaway-Mariano, D.; Metcalf, W.W.; Wanner, B.L.; Martin, B.M. (2002) The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway J Bacteriol 184 4134-40.

Articles on
last changed 2019/01/07 14:42

B6db activities