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B6db activities:
Description (2-aminoethyl)phosphonate--pyruvate aminotransferase.
Alternative names (2-aminoethyl)phosphonate aminotransferase;
Ciliatine transaminase.
Catalyzed reaction (2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine.
Cofactor Pyridoxal-phosphate.
2-Aminoethylphosphonate (ciliatine) is the precursor of an array phosphonated compounds (e.g., phosphonopolysaccharides), that are employed by some organisms for specialized functions such as chemical warfare, cell-cell communication and host recognition.
PDB 1M32;
Organisms -Eubacteria

Family (13)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Chen, C.C., Zhang, H., Kim, A.D., Howard A., Sheldrick, G.M., Mariano-Dunaway, D., Herzberg O. (2002) Degradation pathway of the phosphonate ciliatine: crystal structure of 2-aminoethylphosphonate transaminase Biochemistry 41 13162-69.

 Kim, A.D.; Baker, A.S.; Dunaway-Mariano, D.; Metcalf, W.W.; Wanner, B.L.; Martin, B.M. (2002) The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway J Bacteriol 184 4134-40.

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last changed 2010/03/11 16:16

B6db activities