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2.6.1.40 |
Description |
(R)-3-amino-2-methylpropionate--pyruvate aminotransferase |
Alternative names |
D-3-aminoisobutyrate--pyruvate aminotransferase; Beta-aminoisobutyrate--pyruvate transaminase;
D-AIB AT;
AGXT2;
alanine-glyoxylate aminotransferase 2;
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Catalyzed reaction |
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine. |
Cofactor |
Pyridoxal-phosphate. |
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The enzyme from rat liver appears to be identical to Alanine--glyoxylate aminotransferase (2.6.1.44), isoenzyme 2. |
Diseases |
Hyper-beta-aminoisobutyricaciduria |
Organisms |
-Plants -Metazoa -Human |
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Family |
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Links |
Enzyme (activities) 2.6.1.40
BRENDA (activities) 2.6.1.40
KEGG (pathways) 2.6.1.40
PLPMDB (PLP mutants) 2.6.1.40
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References |
Parthasarathy A, Adams LE, Savka FC, Hudson AO (2019) The Arabidopsis thaliana gene annotated by the locus tag At3g08860 encodes alanine aminotransferase Plant direct 3 e00171. Rodionov RN, Murry DJ, Vaulman SF, Stevens JW, Lentz SR. (2010) Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production J Biol Chem 285 5385-91. Lee, I. S.; Muragaki, Y.; Ideguchi, T.; Hase, T.; Tsuji, M.; Ooshima, A.; Okuno, E.; Kido, R. (1995) Molecular cloning and sequencing of a cDNA encoding alanine-glyoxylate aminotransferase 2 from rat kidney J Biochem (Tokyo) 117 856-62. Kontani, Y.; Kaneko, M.; Kikugawa, M.; Fujimoto, S.; Tamaki, N. (1993) Identity of D-3-aminoisobutyrate-pyruvate aminotransferase with alanine- glyoxylate aminotransferase 2 Biochim Biophys Acta 1156 161-6. Okuno, E.; Minatogawa, Y.; Kido, R. (1982) Co-purification of alanine-glyoxylate aminotransferase with 2- aminobutyrate aminotransferase in rat kidney Biochim Biophys Acta 715 97-104.. Articles on 2.6.1.40 |
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last changed |
2019/09/19 12:21 |
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