B6db activities : 2_6_1

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	2.6.1.42
Description	Branched-chain amino acid aminotransferase.
Alternative names	Transaminase B.
Catalyzed reaction	L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
Cofactor	Pyridoxal-phosphate.
Comments	-!- Also acts on L-isoleucine and L-valine. -!- Different from EC 2.6.1.66.
	The human cytosolic enzyme is a direct target for c-Myc regulation, and seems somehow involved in apoptosis.
Prosite	PROSITE; PDOC00618;
PDB	1I1K; 1EKF; 1EKV;
Organisms	-All -Eubacteria -Archea -Plants -Fungi -Metazoa -Human
Family	2.6.1.42 (38) 2.6.1.42 b (5)

Links	Enzyme (activities) 2.6.1.42 BRENDA (activities) 2.6.1.42 KEGG (pathways) 2.6.1.42 PLPMDB (PLP mutants) 2.6.1.42

References	Uchida Y, Hayashi H, Washio T, Yamasaki R, Kato S, Oikawa T. (2014 ) Cloning and characterization of a novel fold-type I branched-chain amino acid aminotransferase from the hyperthermophilic archaeon Thermococcus sp. CKU-1. Extremophiles. . Schuster J, Binder S. (2005) The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana Plant Mol Biol 57 241-54. Venos ES, Knodel MH, Radford CL, Berger BJ. (2004) Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis BMC Microbiol 4 39. Berger, B.J.; English, S.; Chan, G.; Knodel, M.H. (2003) Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis J Bacteriol 185 2418-31. Madsen, S.M.; Beck, H.C.; Ravn, P.; Vrang, A.; Hansen, A.M.; Israelsen, H. (2002) Cloning and inactivation of a branched-chain-amino-acid aminotransferase gene from Staphylococcus carnosus and characterization of the enzyme Appl Environ Microbiol 68 4007-14. Yvon, M.; Chambellon, E.; Bolotin, A.; Roudot-Algaron, F. (2000) Characterization and role of the branched-chain aminotransferase (BcaT) isolated from Lactococcus lactis subsp. cremoris NCDO 763 Appl Environ Microbiol 66 571-7. Eden, A.; Benvenisty, N. (1999) Involvement of branched-chain amino acid aminotransferase (Bcat1/Eca39) in apoptosis FEBS Lett 457 255-61. Eden, A.; Benvenisty, N. (1998) Characterization of a branched-chain amino-acid aminotransferase from Schizosaccharomyces pombe Yeast 14 189-94. Bledsoe, R.K.; Dawson, P.A.; Hutson, S.M. (1997) Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm) Biochim Biophys Acta 1339 9-13. Feild MJ, Nguyen DC, Armstrong FB. (1989 ) Amino acid sequence of Salmonella typhimurium branched-chain amino acid aminotransferase Biochemistry 28 5306-10. Inoue, K.; Kuramitsu, S.; Aki, K.; Watanabe, Y.; Takagi, T.; Nishigai, M.; Ikai, A.; Kagamiyama, H. (1988) Branched-chain amino acid aminotransferase of Escherichia coli: overproduction and properties J Biochem (Tokyo) 104 777-84. Articles on 2.6.1.42

last changed	2010/03/11 16:18

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