B6db activities : 2_6_1

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	2.6.1.44
Description	Alanine--glyoxylate aminotransferase.
Alternative names	L-alanine-glyoxylate transaminase; L-alanine-glycine transaminase; AGT; AGXT.
Catalyzed reaction	L-alanine + glyoxylate = pyruvate + glycine.
Cofactor	Pyridoxal-phosphate.
Comments	-!- With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. A second component also catalyzes the reaction of EC 2.6.1.51.
	The isoenzyme alanine:glyoxylate aminotransferase 1 from rat liver organelles is identical to serine-pyruvate aminotransferase (2.6.1.51) and asparagine-oxo-acid aminotransferase (2.6.1.14)[Noguchi & Fujiwara (1988) JBC 263, 182]. Sequences for this enzyme are listed under 2.6.1.51. The eukariotic sequences included in family a are close homologs of alanine:glyoxylate aminotransferase 2 from rat liver; this enzyme appears to be identical to (D)-3-amino-2-methylpropanoate aminotransferase (2.6.1.40) and aminolevulinate aminotransferase (2.6.1.43). The archaeal sequences included in family b are not closely related to the eukariotic enzymes with alanine-glyoxylate aminotransferase activity.
Diseases	Primary hyperoxaluria type 1 (?) Hyper-beta-aminoisobutyricaciduria (?)
Prosite	PROSITE; PS00600;
PDB	2ZC0;
Organisms	-Eubacteria -Archea -Plants -Fungi -Metazoa -Human
Family	2.6.1.44_a (14) 2.6.1.44_b (8)

Links	Enzyme (activities) 2.6.1.44 BRENDA (activities) 2.6.1.44 KEGG (pathways) 2.6.1.44 PLPMDB (PLP mutants) 2.6.1.44

References	Rodionov RN, Murry DJ, Vaulman SF, Stevens JW, Lentz SR. (2010) Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production J Biol Chem 285 5385-91. Sakuraba H, Yoneda K, Takeuchi K, Tsuge H, Katunuma N, Ohshima T. (2008) Structure of an archaeal alanine:glyoxylate aminotransferase Acta Crystallogr D Biol Crystallogr 64 696-9. Sakuraba, H.; Kawakami, R.; Takahashi, H.; Ohshima, T. (2004) Novel archaeal alanine:glyoxylate aminotransferase from Thermococcus litoralis J Bacteriol 186 15292154. Lee, I. S.; Muragaki, Y.; Ideguchi, T.; Hase, T.; Tsuji, M.; Ooshima, A.; Okuno, E.; Kido, R. (1995) Molecular cloning and sequencing of a cDNA encoding alanine-glyoxylate aminotransferase 2 from rat kidney J Biochem (Tokyo) 117 856-62. Okuno, E.; Minatogawa, Y.; Kido, R. (1982) Co-purification of alanine-glyoxylate aminotransferase with 2- aminobutyrate aminotransferase in rat kidney Biochim Biophys Acta 715 97-104.. Articles on 2.6.1.44

last changed	2010/03/11 16:21

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