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B6db activities:
Description Tyrosine aminotransferase.
Alternative names Tyrosine transaminase;
Catalyzed reaction L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
Cofactor Pyridoxal-phosphate.
Comments -!- L-phenylalanine can act instead of L-tyrosine.
-!- The mitochondrial enzyme may be identical with EC
-!- The three isoenzymic forms are interconverted by EC
May overlap with
Diseases Tyrosinemia II (Richner-Hanhart syndrome)
Prosite PROSITE; PDOC00098;
Organisms -Eubacteria -Plants -Fungi -Metazoa -Human

Family (20)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Riewe D, Koohi M, Lisec J, Pfeiffer M, Lippmann R, Schmeichel J, Willmitzer L, Altmann T. (2012) A tyrosine aminotransferase involved in tocopherol synthesis in Arabidopsis. Plant J 71 850-9.

 Sivaraman S, Kirsch JF. (2006) The narrow substrate specificity of human tyrosine aminotransferase--the enzyme deficient in tyrosinemia type II. FEBS J 273 1920-9.

 Lopukhina, A.; Dettenberg, M.; Weiler, E.W.; Hollander-Czytko, H. (2001) Cloning and characterization of a coronatine-regulated tyrosine aminotransferase from Arabidopsis Plant Physiol 126 1678-87.

 Blankenfeldt, W.; Nowicki, C.; Montemartini-Kalisz, M.; Kalisz, HM.; Hecht, HJ. (1999) Crystal structure of Trypanosoma cruzi tyrosine aminotransferase: substrate specificity is influenced by cofactor binding mode Protein Sci 8 2406-17.

 Dietrich, J. B.; Lorber, B.; Kern, D. (1991) Expression of mammalian tyrosine aminotransferase in Saccharomyces cerevisiae and Escherichia coli. Purification to homogeneity and characterization of the enzyme overproduced in the bacteria Eur J Biochem 201 399-407.

 Grange, T.; Guenet, C.; Dietrich, J.B.; Chasserot, S.; Fromont, M.; Befort, N.; Jami, J.; Beck, G.; Pictet, R. (1985) Complete complementary DNA of rat tyrosine aminotransferase messenger RNA. Deduction of the primary structure of the enzyme J Mol Biol 184 347-50.

Articles on
last changed 2010/02/02 10:16

B6db activities