B6db activities : 2_6_1

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	2.6.1.5
Description	Tyrosine aminotransferase
Alternative names	Tyrosine transaminase; TAT.
Catalyzed reaction	L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
Cofactor	Pyridoxal-phosphate.
Comments	-!- L-phenylalanine can act instead of L-tyrosine. -!- The mitochondrial enzyme may be identical with EC 2.6.1.1. -!- The three isoenzymic forms are interconverted by EC 3.4.22.4.
	May overlap with 2.6.1.57
Diseases	Tyrosinemia II (Richner-Hanhart syndrome)
Prosite	PROSITE; PDOC00098;
PDB	1BW0; 4IX8;
Organisms	-Eubacteria -Plants -Fungi -Metazoa -Human
Family	2.6.1.5_a (0) 2.6.1.5_b (0)

Links	Enzyme (activities) 2.6.1.5 BRENDA (activities) 2.6.1.5 KEGG (pathways) 2.6.1.5 PLPMDB (PLP mutants) 2.6.1.5

References	Ru M, Wang K, Bai Z, Peng L, He S, Wang Y, Liang Z (2017) A tyrosine aminotransferase involved in rosmarinic acid biosynthesis in Prunella vulgaris L Sci Rep 7 4892. Kilpatrick K, Pajak A, Hagel JM, Sumarah MW, Lewinsohn E, Facchini PJ, Marsolais F. (2016) Characterization of aromatic aminotransferases from Ephedra sinica Stapf Amino Acids 48 1209-20. Moreno MA, Abramov A, Abendroth J, Alonso A, Zhang S, Alcolea PJ, Edwards T, Lorimer D, Myler PJ, Larraga V. (2014) Structure of tyrosine aminotransferase from Leishmania infantum Acta Crystallogr F Struct Biol Commun 70 583-7. Riewe D, Koohi M, Lisec J, Pfeiffer M, Lippmann R, Schmeichel J, Willmitzer L, Altmann T. (2012) A tyrosine aminotransferase involved in tocopherol synthesis in Arabidopsis. Plant J 71 850-9. Schneider P, Bouhired S, Hoffmeister D. (2008) Characterization of the atromentin biosynthesis genes and enzymes in the homobasidiomycete Tapinella panuoides Fungal Genet Biol 45 1487-96. Sivaraman S, Kirsch JF. (2006) The narrow substrate specificity of human tyrosine aminotransferase--the enzyme deficient in tyrosinemia type II. FEBS J 273 1920-9. Lopukhina, A.; Dettenberg, M.; Weiler, E.W.; Hollander-Czytko, H. (2001) Cloning and characterization of a coronatine-regulated tyrosine aminotransferase from Arabidopsis Plant Physiol 126 1678-87. Blankenfeldt, W.; Nowicki, C.; Montemartini-Kalisz, M.; Kalisz, HM.; Hecht, HJ. (1999) Crystal structure of Trypanosoma cruzi tyrosine aminotransferase: substrate specificity is influenced by cofactor binding mode Protein Sci 8 2406-17. Dietrich, J. B.; Lorber, B.; Kern, D. (1991) Expression of mammalian tyrosine aminotransferase in Saccharomyces cerevisiae and Escherichia coli. Purification to homogeneity and characterization of the enzyme overproduced in the bacteria Eur J Biochem 201 399-407. Grange, T.; Guenet, C.; Dietrich, J.B.; Chasserot, S.; Fromont, M.; Befort, N.; Jami, J.; Beck, G.; Pictet, R. (1985) Complete complementary DNA of rat tyrosine aminotransferase messenger RNA. Deduction of the primary structure of the enzyme J Mol Biol 184 347-50. Articles on 2.6.1.5

last changed	2017/12/22 09:55

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