B6db activities : 2_6_1

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	2.6.1.5
Description	Tyrosine aminotransferase.
Alternative names	Tyrosine transaminase; TAT.
Catalyzed reaction	L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
Cofactor	Pyridoxal-phosphate.
Comments	-!- L-phenylalanine can act instead of L-tyrosine. -!- The mitochondrial enzyme may be identical with EC 2.6.1.1. -!- The three isoenzymic forms are interconverted by EC 3.4.22.4.
	May overlap with 2.6.1.57
Diseases	Tyrosinemia II (Richner-Hanhart syndrome)
Prosite	PROSITE; PDOC00098;
PDB	1BW0;
Organisms	-Eubacteria -Plants -Fungi -Metazoa -Human
Family	2.6.1.5 (20)

Links	Enzyme (activities) 2.6.1.5 BRENDA (activities) 2.6.1.5 KEGG (pathways) 2.6.1.5 PLPMDB (PLP mutants) 2.6.1.5

References	Riewe D, Koohi M, Lisec J, Pfeiffer M, Lippmann R, Schmeichel J, Willmitzer L, Altmann T. (2012) A tyrosine aminotransferase involved in tocopherol synthesis in Arabidopsis. Plant J 71 850-9. Sivaraman S, Kirsch JF. (2006) The narrow substrate specificity of human tyrosine aminotransferase--the enzyme deficient in tyrosinemia type II. FEBS J 273 1920-9. Lopukhina, A.; Dettenberg, M.; Weiler, E.W.; Hollander-Czytko, H. (2001) Cloning and characterization of a coronatine-regulated tyrosine aminotransferase from Arabidopsis Plant Physiol 126 1678-87. Blankenfeldt, W.; Nowicki, C.; Montemartini-Kalisz, M.; Kalisz, HM.; Hecht, HJ. (1999) Crystal structure of Trypanosoma cruzi tyrosine aminotransferase: substrate specificity is influenced by cofactor binding mode Protein Sci 8 2406-17. Dietrich, J. B.; Lorber, B.; Kern, D. (1991) Expression of mammalian tyrosine aminotransferase in Saccharomyces cerevisiae and Escherichia coli. Purification to homogeneity and characterization of the enzyme overproduced in the bacteria Eur J Biochem 201 399-407. Grange, T.; Guenet, C.; Dietrich, J.B.; Chasserot, S.; Fromont, M.; Befort, N.; Jami, J.; Beck, G.; Pictet, R. (1985) Complete complementary DNA of rat tyrosine aminotransferase messenger RNA. Deduction of the primary structure of the enzyme J Mol Biol 184 347-50. Articles on 2.6.1.5

last changed	2010/02/02 10:16

Family