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B6db activities:
Description Aromatic amino acid transaminase
Catalyzed reaction An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
Cofactor Pyridoxal-phosphate.
Comments -!- L-methionine can also act as donor, more slowly.
-!- Oxaloacetate can act as acceptor.
-!- Controlled proteolysis converts the enzyme to EC include
Often enzymes with this activity are related to aspartate aminotransferase enzymes (EC

Sequences in family a are most similar to aspartate aminotransferases in families and

Sequences in family b are most similar to enzymes belonging to family

At variance with the above, sequences in family c are most similar to histidinol phosphate aminotransferases, family

A yeast gene encoding a transaminase with broad substrate specificity is sometimes annotated as aromatic aminoacid aminotransferase, but it apparently prefers 2-aminoadipate as a substrate and is included in family

Prosite PROSITE; PDOC00098;
PDB 1AY4; 3TAT; 1DJU; 1GD9; 4R5Z; 4RKC;
Organisms -Eubacteria -Archea -Fungi -Metazoa

Family (14) (15) (18)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Nasir N, Anant A, Vyas R, Biswal BK (2016) Crystal structures of Mycobacterium tuberculosis HspAT and ArAT reveal structural basis of their distinct substrate specificities Sci Rep 6 18880.

 Bujacz A, Rutkiewicz-Krotewicz M, Nowakowska-Sapota K, Turkiewicz M (2015) Crystal structure and enzymatic properties of a broad substrate-specificity psychrophilic aminotransferase from the Antarctic soil bacterium Psychrobacter sp. B6 Acta Crystallogr D Biol Crystallogr 71 632-45.

 Marienhagen J, Kennerknecht N, Sahm H, Eggeling L. (2005) Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum J Bacteriol 187 7639-46.

 Matsui, I.; Matsui, E.; Sakai, Y.; Kikuchi, H.; Kawarabayasi, Y.; Ura, H.; Kawaguchi, S.; Kuramitsu, S.; Harata, K. (2000) The molecular structure of hyperthermostable aromatic aminotransferase with novel substrate specificity from Pyrococcus horikoshii J Biol Chem 275 4871-9.

 Heilbronn, J.; Wilson, J.; Berger, B.J. (1999) Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae J Bacteriol 181 1739-47.

 Rijnen, L.; Bonneau, S.; Yvon, M. (1999) Genetic characterization of the major lactococcal aromatic aminotransferase and its involvement in conversion of amino acids to aroma compounds Appl Environ Microbiol 65 4873-80..

 Gu, W.; Song, J.; Bonner, C.A.; Xie, G.; Jensen, R.A. (1998) PhhC is an essential aminotransferase for aromatic amino acid catabolism in Pseudomonas aeruginosa Microbiology 144 3127-34.

 Oue, S.; Okamoto, A.; Nakai, Y.; Nakahira, M.; Shibatani, T.; Hayashi, H.; Kagamiyama, H. (1997) Paracoccus denitrificans aromatic amino acid aminotransferase: a model enzyme for the study of dual substrate recognition mechanism J Biochem (Tokyo) 121 161-71.

 Hayashi, H.; Inoue, K.; Nagata, T.; Kuramitsu, S.; Kagamiyama, H. (1993) Escherichia coli aromatic amino acid aminotransferase: characterization and comparison with aspartate aminotransferase Biochemistry 32 12229-39.

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last changed 2019/06/21 13:04

B6db activities