B6db activities : 2_6_1

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	2.6.1.58
Description	Phenylalanine(histidine) aminotransferase
Catalyzed reaction	L-phenylalanine + pyruvate = phenylpyruvate + L-alanine.
Cofactor	Pyridoxal-phosphate.
Comments	-!- L-histidine and L-tyrosine can act instead of L-phenylalanine, in the reverse reaction, L-methionine, l-serine and L-glutamine can replace L-alanine.
	A phenylalanine transaminase from Pseudomonas (Paracoccus) denitrificans has been later classified as an aromatic amino acid aminotransferase (EC 2.6.1.57) and is included in family 2.6.1.57_a.
Organisms	-Metazoa -Human
Family	2.6.1.58 (0)

Links	Enzyme (activities) 2.6.1.58 BRENDA (activities) 2.6.1.58 KEGG (pathways) 2.6.1.58 PLPMDB (PLP mutants) 2.6.1.58

References	Wackler B, Schneider P, Jacobs JM, Pauly J, Allen C, Nett M, Hoffmeister D (2011) Ralfuranone biosynthesis in Ralstonia solanacearum suggests functional divergence in the quinone synthetase family of enzymes Chem Biol 18 354-60. Takagi, T.; Taniguchi, T.; Yamamoto, Y.; Shibatani, T. (1991) Molecular cloning of the L-phenylalanine transaminase gene from Paracoccus denitrificans in Escherichia coli K-12 Biotechnol Appl Biochem. 13 112-9. Noguchi, T.; Okuno, E.; Kido, R. (1977) Identity of rat kidney histidine-pyruvate aminotransferase with glutamine-oxo acid aminotransferase Biochem J 161 177-9. Articles on 2.6.1.58

last changed	2019/04/18 12:44

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