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B6db activities: 2.6.1.7

2.6.1.7
Description Kynurenine--oxoglutarate aminotransferase.
Alternative names Kynurenine aminotransferase;
KATI;
KATIII.
Catalyzed reaction L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
Cofactor Pyridoxal-phosphate.
Comments -!- Also acts on 3-hydroxykynurenine.
-!- include 2.6.1.64 and 4.4.1.13
In rat, kynurenine aminotransferase I also possesses alpha-aminoadipate aminotransferase activity (2.6.1.39). In T. thermophilus, a single enzyme has been found responsible for the kynurenine-oxoglutarate aminotransferase reaction and for the glutamine-phenylpyruvate reaction (2.6.1.64).

In E. coli, the transamination of kynurenine is apparently carried out by aspartate aminotransferase (2.6.1.1).

Finally, note that the transamination of 3-hydroxykynurenine in insects is carried out by an enzyme phylogenetically related to Serine--pyruvate aminotransferase (2.6.1.51)

PDB 1YIZ; 3B46;
Organisms -Eubacteria -Fungi -Metazoa -Human
 

Family 

2.6.1.7 (24)
 
Links Enzyme (activities) 2.6.1.7
BRENDA (activities) 2.6.1.7
KEGG (pathways) 2.6.1.7
PLPMDB (PLP mutants) 2.6.1.7
 
References
 Battsetseg B, Boldbaatar D, Battur B, Xuan X, Fujisaki K. (2009) Cloning and molecular characterization of tick kynurenine aminotransferase (HlKAT) from Haemaphysalis longicornis (Acari: Ixodidae). Parasitol Res. 105 669-79.

 Han Q1, Robinson H, Cai T, Tagle DA, Li J. (2009) Biochemical and structural properties of mouse kynurenine aminotransferase III Mol Cell Biol 29 784-93.

 Wogulis M, Chew ER, Donohoue PD, Wilson DK. (2008) Identification of Formyl Kynurenine Formamidase and Kynurenine Aminotransferase from Saccharomyces cerevisiae Using Crystallographic, Bioinformatic and Biochemical Evidence Biochemistry 47 1608-21.

 Han, Q.; Li, J.; Li, J. (2004) pH dependence, substrate specificity and inhibition of human kynurenine aminotransferase I Eur J Biochem 271 4804-14.

 Rossi, F.; Han, Q.; Li, J.; Li, J.; Rizzi, M. (2004) Crystal structure of human kynurenine aminotransferase I J Biol Chem 279 50214-20.

 Hosono, A.; Mizuguchi, H.; Hayashi, H.; Goto, M.; Miyahara, I.; Hirotsu, K.; Kagamiyama, H. (2003) Glutamine:phenylpyruvate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus HB8 J Biochem (Tokyo) 134 843-51.

 Fang, J.; Han, Q.; Li, J. (2002) Isolation, characterization, and functional expression of kynurenine aminotransferase cDNA from the yellow fever mosquito, Aedes aegypti Insect Biochem Mol Biol 32 943-50.

 Han, Q.; Fang, J.; Li, J. (2001) Kynurenine aminotransferase and glutamine transaminase K of Escherichia coli: identity with aspartate aminotransferase Biochem J 360 617-23.

 Mosca, M.; Cozzi, L.; Breton, J.; Avanzi, N.; Toma, S.; Okuno, E.; Schwarcz, R.; Speciale, C.; Magagnin, S.; Mostardini, M.; Benatti, L. (1996) Cloning of rat and human kynurenine aminotransferase Adv Exp Med Biol 398 449-54.

 Buchli, R.; Alberati-Giani, D.; Malherbe, P.; Kohler, C.; Broger, C.; Cesura, A. M. (1995) Cloning and functional expression of a soluble form of kynurenine/alpha- aminoadipate aminotransferase from rat kidney J Biol Chem 270 29330-5.

Articles on 2.6.1.7
 
last changed 2010/09/06 12:41

B6db activities