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2.6.1.77 |
Description |
Taurine--pyruvate aminotransferase |
Alternative names |
taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde |
Cofactor |
Pyridoxal-phosphate. |
Comments |
The enzyme from Bilophila wadsworthia catalyzes a reversible reaction that starts an anaerobic taurine degradation pathway.
Hypotaurine (i.e. 2-aminoethanesulfinate) and beta-alanine are also significant donors of an amino group.
Unlike, EC 2.6.1.55, 2-oxoglutarate is not an acceptor of amino groups. |
Organisms |
-Eubacteria |
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Family |
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Links |
Enzyme (activities) 2.6.1.77
BRENDA (activities) 2.6.1.77
KEGG (pathways) 2.6.1.77
PLPMDB (PLP mutants) 2.6.1.77
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References |
Chen Y, Yi D, Jiang S, Wei D (2016) Identification of novel thermostable taurine-pyruvate transaminase from Geobacillus thermodenitrificans for chiral amine synthesis Appl Microbiol Biotechnol 100 3101-11. Felux AK, Denger K, Weiss M, Cook AM, Schleheck D. (2013) Paracoccus denitrificans PD1222 utilizes hypotaurine via transamination followed by spontaneous desulfination to yield acetaldehyde and, finally, acetate for growth. J Bacteriol. 195 2921-30. Denger K, Ruff J, Schleheck D, Cook AM. (2004) Rhodococcus opacus expresses the xsc gene to utilize taurine as a carbon source or as a nitrogen source but not as a sulfur source Microbiology 150 1859-67. Masepohl, B.; Fuhrer, F.; Klipp, W. (2001) Genetic analysis of a Rhodobacter capsulatus gene region involved in utilization of taurine as a sulfur source FEMS Microbiol Lett 205 105-11. Laue, H; Cook, A.M. (2000) Biochemical and molecular characterization of taurine:pyruvate aminotransferase from the anaerobe Bilophila wadsworthia Eur J Biochem 267 6841-8. Articles on 2.6.1.77 |
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last changed |
2019/05/17 09:18 |
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