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2.6.99.3 |
Description |
O-ureido-L-serine synthase |
Alternative names |
dcsD (gene name);
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Catalyzed reaction |
O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate |
Cofactor |
Pyridoxal-phosphate. |
Comments |
The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species. Also catalyses EC 2.5.1.47, cysteine synthase. |
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The activity (at low level) is also displayed by pyrazolylalanine synthase and the like (see BRENDA). |
PDB |
3X43; |
Organisms |
-Eubacteria |
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Family |
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Links |
Enzyme (activities) 2.6.99.3
BRENDA (activities) 2.6.99.3
KEGG (pathways) 2.6.99.3
PLPMDB (PLP mutants) 2.6.99.3
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References |
Uda N, Matoba Y, Kumagai T, Oda K, Noda M, Sugiyama M. (2013) Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway Antimicrob Agents Chemother 57 2603-12. Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M (2010) Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae Antimicrob Agents Chemother 54 1132-9. Articles on 2.6.99.3 |
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last changed |
2019/06/21 13:07 |
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