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B6db activities:
Description Cysteine desulfurase
Alternative names IscS;
cysteine desulfurylase.
Catalyzed reaction L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine
Cofactor Pyridoxal-phosphate.
Comments The reaction shown is the first part of a catalytic process, which is completed by passing on the protein-bound sulfur to other acceptors.
In Azotobacter vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation. The enzyme is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) and functions by mobilizing sulfur.
Cysteine desulfurases are phylogenetically and functionally related to enzymes such as selenocystine lyases (C-DES type).
They are also phylogenetically related to selenocysteine lyases (EC, and often show some selenocysteine lyase activity.
Diseases Classical xanthinuria type II
PDB 1ECX; 1P3W; 6M4J;
Organisms -Eubacteria -Archea -Plants -Metazoa -Human
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2020/05/08 01:58

B6db activities