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B6db activities: 2.8.1.9

2.8.1.9
Description molybdenum cofactor sulfurtransferase
Alternative names molybdenum cofactor sulfurase;
ABA3;
HMCS;
MoCo sulfurase;
MoCo sulfurtransferase;
L-cysteine:molybdenum cofactor sulfurtransferase.
Catalyzed reaction molybdenum cofactor + L-cysteine + 2 H+ = thio-molybdenum cofactor + L-alanine + H2O
Cofactor Pyridoxal-phosphate.
Comments Contains pyridoxal phosphate. Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide. The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes. In prokaryotes the reaction is catalysed by two enzymes: cysteine desulfurase (EC 2.8.1.7), which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein.
These desulfurases are eukariotic multidomain enzymes involved in the sulfuration of molybdenum enzyzmes such as xanthine oxidase. Additional_domain JC7680 1-500
Organisms -Plants -Metazoa -Human
 

Family 

2.8.1.9 (7)
 
Links Enzyme (activities) 2.8.1.9
BRENDA (activities) 2.8.1.9
KEGG (pathways) 2.8.1.9
PLPMDB (PLP mutants) 2.8.1.9
 
References
 Bittner, F.; Oreb, M.; Mendel, R.R. (2001) ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana J Biol Chem 276 40381-4.

 Ichida, K.; Matsumura, T.; Sakuma, R.; Hosoya, T.; Nishino, T. (2001) Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II Biochem Biophys Res Commun 282 1194-200.

Articles on 2.8.1.9
 
last changed 2014/07/11 16:59

B6db activities