B6db activities : 3_7_1

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	3.7.1.3
Description	Kynureninase.
Alternative names	L-kynurenine hydrolase.
Catalyzed reaction	L-kynurenine + H(2)O = anthranilate + L-alanine.
Cofactor	Pyridoxal-phosphate.
Comments	-!- Also acts on 3'-hydroxykynurenine and some other (3-arylcarbonyl)- alanines.
Diseases	Hydroxykynureninuria
PDB	1QZ9; 2HZP;
Organisms	-Bacteria -Fungi -Metazoa -Human
Family	3.7.1.3 (23)

Links	Enzyme (activities) 3.7.1.3 BRENDA (activities) 3.7.1.3 KEGG (pathways) 3.7.1.3 PLPMDB (PLP mutants) 3.7.1.3

References	Lima S, Khristoforov R, Momany C, Phillips RS. (2007) Crystal structure of Homo sapiens kynureninase Biochemistry 46 2735-44. Momany, C.; Levdikov, V.; Blagova, L.; Lima, S.; Phillips, R.S. (2004) Three-dimensional structure of kynureninase from Pseudomonas fluorescens Biochemistry 43 1193-203.. Walsh, H. A.; Botting, N. P. (2002) Purification and biochemical characterization of some of the properties of recombinant human kynureninase Eur J Biochem 269 2069-74.. Koushik, S. V.; Sundararaju, B.; McGraw, R. A.; Phillips, R. S. (1997) Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens Arch Biochem Biophys 344 301-8.. Toma, S.; Nakamura, M.; Tone, S.; Okuno, E.; Kido, R.; Breton, J.; Avanzi, N.; Cozzi, L.; Speciale, C.; Mostardini, M.; Gatti, S.; Benatti, L. (1997) Cloning and recombinant expression of rat and human kynureninase FEBS Lett 408 5-10. Articles on 3.7.1.3

last changed	2007/12/20 18:52

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